Sororin, the cell cycle and sister chromatid cohesion
Sororin, the cell cycle and sister chromatid cohesion
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DOI：
10.4161/cc.4.8.1926
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发表时间：
2005-08-01
期刊：
影响因子：
4.3
通讯作者：
Rankin, S
中科院分区：
文献类型：
--
作者：
Rankin, S
姐妹染色单体凝聚力对于维持基因组的完整性是必不可少的。凝聚力调节中的错误会导致对DNA损伤、染色体错误分离和遗传信息丢失的敏感性增加。我们最近发现，索洛林是脊椎动物姐妹染色单体凝聚力的重要调节因子。有趣的是，我们在筛选中发现了索洛林，其水平受后期促进复合体(APC)控制，APC是一种细胞周期调节的泛素连接酶。APC的泛素化和由此产生的降解确保了索洛林水平在整个G(1)阶段都很低，只有在S阶段才会上升。我们推测，这种调节是确保只有在事实上有两个姐妹染色单体连接在一起后才能建立凝聚力的机制的重要部分。这样建立的凝聚力既可用于介导重组DNA修复，也可用于确保姐妹染色单体在后期的准确分离。这两个角色对基因组的稳定都是必不可少的。
Sister chromatid cohesion is essential for the maintenance of genome integrity. Errors in regulation of cohesion result in increased sensitivity to DNA damage, mis-segregation of chromosomes, and loss of genetic information. We recently showed that sororin is an essential regulator of sister chromatid cohesion in vertebrates. Interestingly, we identified sororin in a screen for proteins whose levels are controlled by the Anaphase Promoting Complex (APC), a cell cycle-regulated ubiquitin ligase. Ubiquitination by the APC and the resulting degradation ensure that sororin levels are low throughout G(1) and only rise during S phase. We speculate that this regulation is an essential part of the mechanism that ensures that cohesion is established only after there are in fact two sister chromatids to tie together. Cohesion thus established can then be used both to mediate recombinational DNA repair, as well as to ensure accurate sister chromatid segregation in anaphase. Both of these roles are essential to genome stability.