Genetic analysis of self-reported physical activity and adiposity: the Southwest Ohio Family Study.
Genetic analysis of self-reported physical activity and adiposity: the Southwest Ohio Family Study.
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DOI：
10.1017/s1368980008003583
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发表时间：
2009-08
影响因子：
3.2
通讯作者：
Czerwinski SA
中科院分区：
文献类型：
--
作者：
Choh AC;Demerath EW;Lee M;Williams KD;Towne B;Siervogel RM;Cole SA;Czerwinski SA
缺乏身体活动是肥胖和慢性疾病的主要风险，并受到遗传和环境因素的影响。然而，体育活动（PA）水平与肥胖之间的遗传关联尚未得到很好的表征。我们的目标是：(i)在调整家庭影响的同时，估计遗传因素对身体活动的影响程度；（ii）确定体育活动和肥胖措施是否具有共同的遗传效应。样本包括521名成年亲属（42%为男性），年龄在18-86岁之间，来自俄亥俄州西南家庭研究的五个大家庭。运动、休闲和工作PA均为自我报告（Baecke习惯体育活动问卷）。采用双能x线吸收仪测量全身和躯干脂肪，包括体脂百分比（%BF）。用MRI测量腹部内脏和皮下脂肪组织肿块。利用最大似然方差分量法估计了肥胖和PA性状的遗传力，以及它们之间的遗传、家庭和环境相关性。运动PA （h2 = 0.26）和休闲PA （h2 = 0.17）的遗传效应显著（P<0.05）。休闲PA存在显著的家庭效应（P<0.05） （c2 = 0.25）。运动PA与身高调整后的中心性肥胖测量值（ρG>|−0.40|）呈负遗传相关。运动和休闲PA与%BF呈负相关（ρG>| - 0.46|）。研究结果表明，运动和休闲PA与低肥胖之间的联系，部分是由于脂肪减少和更倾向于参加更多体育活动的共同基因遗传。
Physical inactivity poses a major risk for obesity and chronic disease, and is influenced by both genetic and environmental factors. However, the genetic association between physical activity (PA) level and obesity is not well characterized. Our aims were to: (i) estimate the extent of additive genetic influences on physical activity while adjusting for household effects; and (ii) determine whether physical activity and adiposity measures share common genetic effects. The sample included 521 (42% male) adult relatives, 18–86 years of age, from five large families in the Southwest Ohio Family Study. Sport, leisure and work PA were self-reported (Baecke Questionnaire of Habitual Physical Activity). Total body and trunk adiposity, including percentage body fat (%BF), were measured using dual-energy X-ray absorptiometry. Abdominal visceral and subcutaneous adipose tissue mass were measured using MRI. Heritabilities for adiposity and PA traits, and the genetic, household and environmental correlations among them, were estimated using maximum likelihood variance components methods. Significant genetic effects (P<0.05) were found for sport (h2 = 0.26) and leisure PA (h2 = 0.17). Significant (P<0.05) household effects existed for leisure PA (c2 = 0.25). Sport PA had a negative genetic correlation with central adiposity measurements adjusted for height (ρG>|−0.40|). Sport and leisure PA had negative genetic correlations with %BF (ρG>|−0.46|). The results suggest that the association of sport and leisure PA with lower adiposity is due, in part, to a common genetic inheritance of both reduced adiposity and the predisposition to engage in more physical activity.