Effects of thyroid hormones and cold exposure on turnover of norepinephrine in cardiac and skeletal muscle.
Effects of thyroid hormones and cold exposure on turnover of norepinephrine in cardiac and skeletal muscle.
复制标题
甲状腺激素和寒冷暴露对心肌和骨骼肌去甲肾上腺素周转的影响。
DOI：
10.1139/y77-073
复制
发表时间：
1977
影响因子：
2.1
通讯作者：
E. A. Sellers
中科院分区：
文献类型：
--
作者：
J. Tedesco;K. V. Flattery;E. A. Sellers
将[3H]去甲肾上腺素（[3H]NE）静脉注射至保持在23 °C、急性暴露于4 °C并适应于4 °C的甲状腺功能正常、甲状腺功能减退和甲状腺功能亢进大鼠。在注射后10min和6、12和18 h测量心肌比活度的下降（作为周转指数）。 在4 °C下，每个处理组的周转率显著高于23 °C下的周转率。在23 °C时，甲状腺功能减退组的周转率高于甲状腺功能正常组，而甲状腺功能正常组又高于甲状腺功能亢进组（分别为5、8.3和10.8 h的一半（P <0.001））。 在4 °C下12 h后，发现了相同的关系（半衰期分别为1.9、3.5和4.3 h（P <0.001））。 适应4 °C后，甲状腺功能减退组的周转率高于甲状腺功能正常组或甲状腺功能亢进组（P <0.001），半衰期分别为2.1、4.1和3.9 h。 这些值与急性暴露于4 °C的相同处理组的值没有显著差异。最高的周转率是在低血糖大鼠。
[3H]Norepinephrine ([3H]NE) was injected intravenously to euthyroid, hypothyroid, and hyperthyroid rats kept at 23 °C, acutely exposed to 4 °C and acclimated to 4 °C. The decline of specific activity in heart muscle (taken as an index of turnover) was measured at 10 min and , 6, 12, and 18 h after injection. Turnover was significantly higher in each treatment group at 4 °C than at 23 °C. At 23 °C turnover in the hypothyroid group was higher than in the euthyroid, which in turn was higher than in the hyperthyroid group (half times 5, 8.3, and 10.8 h respectively (P < 0.001). After 12 h at 4 °C, the same relationship was found (half times 1.9, 3.5, and 4.3 h respectively (P < 0.001). After acclimation to 4 °C, turnover in the hypothyroid group was higher than in the euthyroid or hyperthyroid groups (P < 0.001) with half times of 2.1, 4.1, and 3.9 h. These values were not significantly different from those of the same treatment groups acutely exposed to 4 °C. The highest turnover rates were in rats with lowe...