HYPERFUNCTION OF THE HYPOTHALAMIC-PITUITARY AXIS IN WOMEN WITH POLYCYSTIC OVARIAN DISEASE - INDIRECT EVIDENCE FOR PARTIAL GONADOTROPH DESENSITIZATION
HYPERFUNCTION OF THE HYPOTHALAMIC-PITUITARY AXIS IN WOMEN WITH POLYCYSTIC OVARIAN DISEASE - INDIRECT EVIDENCE FOR PARTIAL GONADOTROPH DESENSITIZATION
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DOI：
10.1210/jcem-66-1-165
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发表时间：
1988-01-01
影响因子：
5.8
通讯作者：
CROWLEY, WF
中科院分区：
文献类型：
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作者：
WALDSTREICHER, J;SANTORO, NF;CROWLEY, WF
为了研究促性腺激素分泌频率作为多囊卵巢疾病（PCOD）妇女促性腺激素神经内分泌调节紊乱的一个组成部分，我们测定了12名PCOD妇女的血清促性腺激素浓度，间隔10分钟，持续12-24小时。将这些患者的LH和FSH释放模式与21名年龄匹配的正常女性在其周期的早期，中期和晚期卵泡期（EFP，MFP和LFP）的24项研究结果进行比较。在12-24小时的研究中，在PCOD妇女的血清性类固醇水平进行了比较，在卵泡期研究的正常妇女。PCOD组血清E2水平与EFP组相近，而MFP组低于正常组（P
To examine gondotropin secretory frequency as a component of the disordered neuroendocrine regulation of gonadotropin in women with polycystic ovarian disease (PCOD), we measured serum gonadotropin concentrations in 12 women with PCOD at 10-min intervals for periods of 12-24 h. The patterns of LH and FSH release in these patients were compared to the findings of 24 studies in 21 age-matched normal women during the early, mid- and late follicular phases (EFP, MFP and LFP) of their cycles. Serum sex steriod levels during the 12-24 h of study in the women with PCOD were compared to those in normal women studied during the follicular phase. The mean serum estradiol (E2) level in the women with PCOD was similar to that in normal women studied in the EFP, but lower than those in normal women in the MFP (P