Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb
Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb
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DOI：
10.1016/j.cell.2010.04.041
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发表时间：
2010-06-11
期刊：
影响因子：
64.5
通讯作者：
Sakano, Hitoshi
中科院分区：
文献类型：
--
作者：
Takeuchi, Haruki;Inokuchi, Kasumi;Sakano, Hitoshi
在小鼠嗅觉系统中，嗅感觉神经元（OSN）的解剖位置与其沿着嗅球（OB）背腹（D-V）轴的轴突投射部位大致相关。在这里，我们报告的轴突导向受体，神经纤毛蛋白-2（Nrp 2），和它的排斥配体，Sema-phorin-3F（Sema 3F），由OSNs表达的互补的方式，是重要的建立嗅觉地图地形。Sema 3F由OSN的早期到达的轴突分泌，并沉积在前背OB以排斥稍后到达的Nrp 2阳性轴突。OSN轴突的顺序到达以及Nrp 2和Sema 3F的分级和互补表达有助于形成沿着D-V轴的地形秩序。
In the mouse olfactory system, the anatomical locations of olfactory sensory neurons (OSNs) roughly correlate with their axonal projection sites along the dorsal-ventral (D-V) axis of the olfactory bulb (OB). Here we report that an axon guidance receptor, Neuropilin-2 (Nrp2), and its repulsive ligand, Sema-phorin-3F (Sema3F), are expressed by OSNs in a complementary manner that is important for establishing olfactory map topography. Sema3F is secreted by early-arriving axons of OSNs and is deposited at the anterodorsal OB to repel Nrp2-positive axons that arrive later. Sequential arrival of OSN axons as well as the graded and complementary expression of Nrp2 and Sema3F by OSNs help to form the topographic order along the D-V axis.