Cerebrospinal fluid levels of phenylacetic acid in mental illness: behavioral associations and response to neuroleptic treatment.
Cerebrospinal fluid levels of phenylacetic acid in mental illness: behavioral associations and response to neuroleptic treatment.
复制标题
精神疾病中苯乙酸的脑脊液水平：行为关联和对精神安定治疗的反应。
DOI：
10.1111/j.1600-0447.1995.tb09785.x
复制
发表时间：
1995
影响因子：
6.7
通讯作者：
Davis,JM
中科院分区：
文献类型：
--
作者：
Sharma,RP;Faull,K;Javaid,JI;Davis,JM
从正常对照和无药物精神病住院患者（精神分裂症、重度抑郁症、躁狂症和情感障碍）中获得脑脊液苯乙酸水平（CCSF PAA）。在4周抗精神病药物治疗后，从16例患者中获得治疗后CCSF PAA水平。苯乙酸水平在女性中较高，并与年龄显著相关。CCSF PAA水平在不同诊断组之间没有差异，偏执型和非偏执型精神分裂症亚型之间也没有差异。CCSF PAA与几项精神病理学指标显著相关，尤其是简明精神病评定量表的敌意/怀疑因子。抗精神病药物治疗未导致显著的PAA变化。这些研究结果进行了讨论，在光的苯丙胺样作用归因于苯乙胺，PAA的前体。
Cerebrospinal fluid levels of phenylacetic acid (CCSF PAA) were obtained from normal controls and from drug‐free psychiatric inpatients (schizophrenia, major depression, mania, and schizoaffective disorder). Post‐treatment CCSF PAA levels were obtained from 16 patients after 4 weeks of neuroleptic treatment. Phenylacetic acid levels were higher in women and were significantly correlated with age. There were no differences in CCSF PAA levels between the various diagnostic groups and no difference between the paranoid and the nonparanoid subtypes of schizophrenia. CCSF PAA was significantly correlated with several measures of psychopathology, especially the Brief Psychiatric Rating Scale hostility/suspiciousness factor. Neuroleptic treatment did not result in significant PAA changes. These findings are discussed in light of the amphetamine‐like role ascribed to phenylethylamine, the precursor of PAA.