Social dominance in monkeys:: dopamine D2 receptors and cocaine self-administration
Social dominance in monkeys:: dopamine D2 receptors and cocaine self-administration
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DOI：
10.1038/nn798
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发表时间：
2002-02-01
影响因子：
25
通讯作者：
Nader, MA
中科院分区：
文献类型：
--
作者：
Morgan, D;Grant, KA;Nader, MA
多巴胺能系统的破坏与许多病理疾病的病因有关，包括药物成瘾。在这里，我们使用正电子发射断层扫描(PET)成像来研究单独饲养和社会饲养的食蟹猴(n=20)的大脑多巴胺能功能。虽然猴子在个人住房期间没有区别，但社会住房增加了优势猴子体内多巴胺D-2受体的数量或可获得性，而对从属猴子没有影响。这些神经生物学变化对行为产生了重要的影响，这一发现表明，可卡因在从属猴子身上起到了增强剂的作用，但不是占优势的猴子。这些数据表明，生物体环境的变化可以产生深刻的生物学变化，这些变化具有重要的行为关联，包括对可卡因成瘾的脆弱性。
Disruption of the dopaminergic system has been implicated in the etiology of many pathological conditions, including drug addiction. Here we used positron emission tomography (PET) imaging to study brain dopaminergic function in individually housed and in socially housed cynomolgus macaques (n = 20). Whereas the monkeys did not differ during individual housing, social housing increased the amount or availability of dopamine D-2 receptors in dominant monkeys and produced no change in subordinate monkeys. These neurobiological changes had an important behavioral influence as demonstrated by the finding that cocaine functioned as a reinforcer in subordinate but not dominant monkeys. These data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction.