Dietary glycemic index is inversely associated with the risk of Parkinson's disease: A case-control study in Japan
Dietary glycemic index is inversely associated with the risk of Parkinson's disease: A case-control study in Japan
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DOI：
10.1016/j.nut.2009.05.021
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发表时间：
2010-05-01
期刊：
影响因子：
4.4
通讯作者：
Nagai, Masaki
中科院分区：
文献类型：
--
作者：
Murakami, Kentaro;Miyake, Yoshihiro;Nagai, Masaki
目的：高血糖指数（GI）或高血糖负荷（GL）碳水化合物可能通过胰岛素诱导的脑多巴胺增加来降低帕金森病（PD）的风险。我们在日本进行了一项基于医院的病例对照研究，以检查饮食GI和GL与其他饮食碳水化合物变量（包括摄入可用碳水化合物和膳食纤维）和PD之间的关系。方法：招募了使用英国帕金森病协会脑库标准诊断的PD患者（n = 249）和没有神经退行性疾病的对照（n = 368）。在研究招募时，使用经验证的自我施用的饮食摄入评估前一个月期间的饮食摄入。结果：调整潜在的饮食和非饮食混杂因素后。膳食氯与PD的危险性显著相关。多变量比值比（95%置信区间）的PD在第一。一下饮食GI的第三和第四四个四分位数为1.00（参考）。1.03（0 64-1 66）。0.68（0.41 -1.15）和0.61（0.34 -1.09）。趋势P = 0 0 4。其他膳食碳水化合物，包括膳食GL（趋势P = 0.77）观察到显着关联。结论：根据目前饮食习惯进行的初步病例对照研究发现，膳食GI与PD之间存在独立的负相关关系，其机制可能与PD的发生有关。进一步的调查，使用病例对照设计与过去的饮食习惯的准确评估或前瞻性设计是必要的。(C)2010爱思唯尔公司版权所有
Objective: High glycemic index (GI) or glycemic load (GL) carbohydrates might be expected to decrease the risk of Parkinson's disease (PD) by an insulin-induced increase in brain dopamine We conducted a hospital-based case-control study in Japan to examine associations between dietary GI and GL and other dietary carbohydrate variables, including intake of available carbohydrate and dietary fiber, and PDMethods: Patients with PD diagnosed using the U K Parkinson's Disease Society Brain Bank criteria (n = 249) and controls without neurodegenerative diseases (n = 368) were recruited Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered. semiquantitative, comprehensive diet history questionnaire.Results: After adjustment for potential dietary and non-dietary confounding factors. dietary Cl was significantly Inversely associated with the risk of PD. Multivariate odds ratios (95% confidence intervals) for PD in the first. second. third, and fourth quartiles of dietary GI were 1.00 (reference). 1.03 (0 64-1 66). 0 68 (0 4 1-1.15), and 0 61 (0 34-1.09). respectively (P for trend = 0 04) Conversely. 110 significant association was observed for other dietary carbohydrates, including dietary GL (P for trend = 0 77). available carbohydrate intake (P for trend = 0 28), or dietary fiber intake (P for trend = 0 73).Conclusion: This preliminary case-control study based on current dietary habits found an independent inverse relation between dietary GI and PD Considering the plausibility of the putative mechanism. further investigation using a case-control design with accurate assessment of past dietary habits or a prospective design is warranted. (C) 2010 Elsevier Inc All rights reserved