Alarm pheromone that aggravates stress-induced hyperthermia is soluble in water
Alarm pheromone that aggravates stress-induced hyperthermia is soluble in water
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DOI：
10.1093/chemse/bji044
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发表时间：
2005-07-01
期刊：
影响因子：
3.5
通讯作者：
Mori, Y
中科院分区：
文献类型：
--
作者：
Kiyokawa, Y;Kikusui, T;Mori, Y
我们以前曾报道，强调雄性Wistar大鼠释放报警信息素从肛周区域，加重应激诱导的体温过高，并增加Fos的表达在二尖瓣/簇状细胞层的副嗅球在受体大鼠。在这项研究中，我们试图获得这种信息素在水中使用这些反应作为生物测定参数。从没有放置动物的盒子的天花板上收集水滴，或者从对麻醉供体大鼠的颈部或肛周区域给予电刺激以分别诱导颈部气味或警报信息素释放的盒子中收集水滴。然后将三种含水滤纸中的一种放置在受体笼壁上，观察受体的心率、体温和行为反应，以及主嗅球和副嗅球中Fos的表达。从装有报警信息素的盒子中收集的水被发现产生了在我们以前的研究中直接暴露于报警信息素的动物中看到的所有反应的再现。这些结果表明，报警信息素是可溶于水的。
We previously reported that stressed male Wistar rats released alarm pheromone from the perianal region, which aggravated stress-induced hyperthermia and increased Fos expression in the mitral/tufted cell layer of the accessory olfactory bulb in recipient rats. In this study, we attempted to obtain this pheromone in water using these responses as bioassay parameters. Water droplets were collected from the ceiling of a box in which no animal was placed, or from a box in which an anesthetized donor rat was given electrical stimulation to either the neck or perianal regions in order to induce neck odor or alarm pheromone release, respectively. Then we placed one of the three kinds of water-containing filter papers on the wall of a recipient's home cage and observed heart rate, body temperature and behavioral responses, as well as Fos expression in the main and accessory olfactory bulbs of the recipient. The water collected from the box containing the alarm pheromone was found to generate a reproduction of all of the responses seen in the animal that had been directly exposed to alarm pheromone in our previous studies. These results suggest that the alarm pheromone is soluble in water.