A Mechanistic Perspective on the Mechanochemical Method To Reduce Carbonyl Groups with Stainless Steel and Water
A Mechanistic Perspective on the Mechanochemical Method To Reduce Carbonyl Groups with Stainless Steel and Water
复制标题
不锈钢和水机械化学法还原羰基的机理视角
DOI：
10.1002/ejoc.202300149
复制
发表时间：
2023
影响因子：
2.8
通讯作者：
Haley, Rebecca A.
中科院分区：
文献类型：
--
作者：
Mokhtar, Mennatullah M.;Andersen, Joel M.;Kister, Ethan A.;Hopkins, Jordan X.;Estier, Tom;Hamilton, Fiona;Guan, Hairong;Mack, James;Haley, Rebecca A.
通过高速球磨进行的机械化学已成为一种越来越流行的有机转化方法。人们对高速球磨的新兴趣部分是由于在没有溶剂的情况下进行反应的好处所驱动的。机械化学反应通常在带有不锈钢球的不锈钢小瓶中进行。由于不锈钢是由几种容易氧化的金属（铁、铬和镍）制成的，因此使用温控混合研磨机探索了使用水作为氢源的还原反应。机理研究表明，还原反应通过单电子转移（SET）途径进行，其中铁和镍是该反应的重要组成部分。
Mechanochemistry through high‐speed ball milling has become an increasingly popular method for performing organic transformations. This newfound interest in high‐speed ball milling is in part driven by the benefit of performing reactions in the absence of solvent. Mechanochemical reactions are often conducted in stainless‐steel vials with stainless‐steel balls. Since stainless steel is made of several readily oxidizable metals (Fe, Cr, and Ni), reduction reactions using water as a hydrogen source were explored using a temperature‐controlled mixer mill. Mechanistic studies suggest that the reduction proceeds via a single electron transfer (SET) pathway, with iron and nickel being essential components for the reaction.