Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment
Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment
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DOI：
10.1038/sj.mp.4000650
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发表时间：
2000-03-01
影响因子：
11
通讯作者：
Kirchner, H
中科院分区：
文献类型：
--
作者：
Arolt, V;Rothermundt, M;Kirchner, H
在精神分裂症患者中也报道了一种典型的自身免疫性疾病的t细胞细胞因子系统畸变模式，即白细胞介素-2 （IL-2）产生减少和可溶性1L-2受体（sIL-2R）水平升高。也有报道称，干扰素γ (ifn - γ)的产生可能会降低。在纵向设计中，我们研究了精神分裂症患者在治疗期间ifn - γ和IL-2的产生及其相关性，并调查了细胞因子产生与临床变量之间是否存在关联。在年龄和性别相匹配的精神分裂症患者（DSM-IV）和对照组中，对相同数量（n = 29）的ifn - γ和1L-2的产生进行了测量。患者在入院后1天（T1）、治疗后14天（T2）和治疗后28天（T2）进行测量。在这些时间之后进行精神病理学评估。在整个调查期间（T1-T3），患者的ifn - γ和IL-2的产生均显著低于对照组，两种细胞因子的产生在对照组（r = 0.60， P小于或等于0.001）以及精神分裂症患者（T1-T3的平均产生：r = 0.71， P小于或等于0.007）中均显著相关，细胞因子测量与精神病理或发病年龄之间未发现关联。我们发现ifn - γ和IL-2的产生降低且相关，这表明精神分裂症患者细胞因子系统的改变可能与自身免疫性疾病相似。这表明这些免疫异常与精神分裂症的急性加重有关，而不是与精神分裂症的临床亚型有关。
A pattern of aberrations in the T-cell cytokine system that is typical for autoimmune disorders has also been reported in patients with schizophrenia, namely a decreased interleukin-2 (IL-2) production and increased levels of the soluble 1L-2 receptor (sIL-2R). It has also been reported that the production of interferon-gamma (IFN-gamma) may be lowered. In a longitudinal design, we studied the production of both IFN-gamma and IL-2 and their correlation in patients with schizophrenia during treatment and investigated whether associations exist between cytokine production and clinical variables. The production of IFN-gamma and 1L-2 was measured in equal numbers (n = 29) of patients with schizophrenia (DSM-IV) and controls who were matched for age and gender. Patients were measured 1 day after admission (T1), after 14 (T2) and 28 (T2) days of treatment. Psychopathology was assessed after these times. The production of both IFN-gamma and IL-2 was significantly lower in patients than in controls throughout the whole investigation period (T1-T3), The productions of both cytokines were significantly correlated in controls (r = 0.60, P less than or equal to 0.001) as well as in patients with schizophrenia (mean production T1-T3: r = 0.71, P less than or equal to 0.007), No associations between cytokine measurements and psychopathology or age-at-onset could be found. Our findings of lowered and correlated IFN-gamma and IL-2 production indicate that alterations in the cytokine system of patients with schizophrenia might resemble those in autoimmune disorders. It is suggested that these immunological abnormalities are associated with acute exacerbation, rather than with a clinical subtype of schizophrenia.