Prenatal diagnosis and treatment of fetal long QT syndrome: a case report
Prenatal diagnosis and treatment of fetal long QT syndrome: a case report
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胎儿长QT综合征的产前诊断与治疗1例报告
DOI：
10.1002/pd.475
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发表时间：
2002
影响因子：
3
通讯作者：
F. Hsieh
中科院分区：
文献类型：
--
作者：
I. Chang;M. Shyu;Chien;M. Kau;Yu;S. Chow;F. Hsieh
我们报告一例胎儿在妊娠中期出现心动过缓、间歇性房室（AV）传导阻滞、室性心动过速（VT）和胎儿充血性心力衰竭（腹水和阴囊积液）的体征。由于怀疑胎儿充血性心力衰竭发生长QT综合征，因此使用β-肾上腺素能阻滞剂（普萘洛尔）和洋地黄苷进行产前治疗。男婴在妊娠39周时出生，表现出QT间期延长（QTc = 492 ms）和频繁的可变AV阻滞或交替的左右束分支阻滞，取决于心房率。产前利多卡因给药未能纠正胎儿室性心动过速。相反，心得安降低胎儿室性心动过速的发作频率。出生后给予K+通道开放剂（尼可地尔）成功缩短了QT间期并改善了结局。版权所有© 2002年约翰威利父子有限公司。
We report a case of a fetus presenting with bradycardia, intermittent atrioventricular (AV) block, ventricular tachycardia (VT) and the signs of fetal congestive heart failure (ascites and scrotal hydrocele) during mid‐gestation. Prenatal treatment with β‐adrenergic blocker (propranolol) and digitalis glycosides was prescribed because of suspicion of long QT syndrome occurring with fetal congestive heart failure. The male baby was born at 39 weeks of gestation and showed a prolonged QT interval (QTc = 492 ms) and frequent variable AV block or alternating left and right bundle branch block, depending on the atrial rate. Prenatal administration of lidocaine failed to correct the fetal VT. Conversely, propranolol decreased the attack frequency of fetal VT. Postnatal administration of the K+ channel opener (nicorandil) successfully shortened the QT interval and improved the outcome. Copyright © 2002 John Wiley & Sons, Ltd.