Survivin expression is a prognostic marker in pancreatic cancer patients
Survivin expression is a prognostic marker in pancreatic cancer patients
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DOI：
10.1016/j.surg.2004.05.023
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发表时间：
2004-08-01
期刊：
影响因子：
3.8
通讯作者：
Imamura, M
中科院分区：
文献类型：
--
作者：
Kami, K;Doi, R;Imamura, M
背景。在这项研究中，我们评估了接受单独胰腺切除术或胰腺切除加术后放射治疗 (PORT) 的患者的胰腺癌标本中生存素的表达，以评估生存素表达是否可以预测胰腺癌患者对 PORT 的敏感性和结果。 方法。本研究纳入了 52 名因导管腺癌接受胰腺切除术的患者。通过免疫组织化学评估了 47 例胰腺导管腺癌和 5 例正常胰腺组织的生存素表达。分析survivin表达与临床病理数据的关系。结果。百分之六十八（32/47）的胰腺癌组织的存活蛋白表达呈阳性； 32% (15/47) 的结果是否定的。正常胰腺外分泌组织的存活蛋白表达呈阴性（0/5）。 survivin 阳性患者的生存期明显短于 survivin 阴性患者 (P = .02)。生存素是一个与总生存率相关的自变量 (P = .01)。有和没有 PORT 的患者之间的生存时间没有差异。很可能，PORT 对 survivin 阳性患者 (P = .12) 以及 survivin 阴性患者的生存时间没有影响。 (P = .95)。结论。结果表明，胰腺癌组织中生存素的表达可能是胰腺癌患者的一个有用的预后标志物。
Background. In this study, we assessed survivin expression in pancreatic cancer specimens from patients who underwent either pancreatic resection alone or pancreatic resection plus postoperative radiation therapy (PORT) to evaluate whether survivin expression is predictive of sensitivity to PORT and outcome in pancreatic cancer patients.Methods. Fifty-two patients who underwent pancreatic resection for ductal adenocarcinomas were included in this study. Forty-seven pancreatic ductal adenocarcinoma and 5 normal pancreatic tissues were evaluated for survivin expression by immunohistochemistry. Then the relationship between survivin expression and clinicopathologic data were analyzed.Results. Sixty-eight percent (32/47) of pancreatic cancer tissues were positive for survivin expression; 32% (15/47) were negative. Normal pancreatic exocrine tissues were negative for survivin expression (0/5). Survival of the patients with positive survivin was significantly shorter than those with negative survivin (P = .02). Survivin was an independent variable that correlated with overall survival (P = .01). There was no difference in survival time between patients with and without PORT Likely, PORT showed no impact on survival time in survivin-positive patients (P = .12) as, well as in survivin-negative patients. (P = .95).Conclusions. The results suggest that survivin expression in pancreatic cancer tissues could be a useful prognostic marker in pancreatic cancer patients.