Circulating signals as critical regulators of autonomic state--central roles for the subfornical organ.
Circulating signals as critical regulators of autonomic state--central roles for the subfornical organ.
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DOI：
10.1152/ajpregu.00103.2010
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Pauline M. Smith;A. Ferguson
中科院分区：
文献类型：
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作者：
Pauline M. Smith;A. Ferguson
为了维持体内平衡，下丘脑和髓质的自主控制中心必须对外部和内部刺激作出适当的反应。尽管受到血脑屏障的保护，这些自主控制中心的神经元受到体循环中重要信号分子（如渗透压、葡萄糖浓度和调节肽）水平变化的影响。皮层下器官属于一组特殊的中枢神经系统结构，即脑室周围器官，其特点是缺乏正常的血脑屏障，因此循环的疏脂物质可能作用于该区域内的神经元，并通过充分记录的下丘脑自主神经控制中心的传出神经投射影响自主神经功能。本文综述了皮层下器官在感知外周信号并将其传递到下丘脑自主控制中心中的作用。
To maintain homeostasis autonomic control centers in the hypothalamus and medulla must respond appropriately to both external and internal stimuli. Although protected behind the blood-brain barrier, neurons in these autonomic control centers are known to be influenced by changing levels of important signaling molecules in the systemic circulation (e.g., osmolarity, glucose concentrations, and regulatory peptides). The subfornical organ belongs to a group of specialized central nervous system structures, the circumventricular organs, which are characterized by the lack of the normal blood-brain barrier, such that circulating lipophobic substances may act on neurons within this region and via well-documented efferent neural projections to hypothalamic autonomic control centers, influence autonomic function. This review focuses on the role of the subfornical organ in sensing peripheral signals and transmitting this information to autonomic control centers in the hypothalamus.