Preservation of alveolar ridge height through mechanical memory: A novel dental implant design
Preservation of alveolar ridge height through mechanical memory: A novel dental implant design
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DOI：
10.1016/j.bioactmat.2020.07.015
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发表时间：
2020-08
影响因子：
18.9
通讯作者：
S. Yin;Wenjie Zhang;Yanmei Tang;Guangzheng Yang;Xiaolin Wu;Sihan Lin;Xuanyong Liu;H. Cao
中科院分区：
文献类型：
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作者：
S. Yin;Wenjie Zhang;Yanmei Tang;Guangzheng Yang;Xiaolin Wu;Sihan Lin;Xuanyong Liu;H. Cao
不可逆的边缘骨丢失会阻碍种植体周围的恢复。咀嚼过程中牙槽骨生成不足和应力集中会导致边缘骨吸收，并可能导致种植体失败。利用3D打印技术开发了一种具有微孔通道结构的生物材料。这种设计促进了骨长入，并在咀嚼天然牙齿的过程中在种植体颈提供了类似的机械刺激。微孔通道为骨髓间充质干细胞的增殖和分化提供了一种导向结构，而不需要生长因子。具体地说，这是通过F-肌动蛋白重塑和YAP激活的机械转导实现的。这些种植体在犬牙种植手术模型中得到了验证，这表明基于生物材料的种植体在未来的临床应用中具有广阔的应用前景。
Irreversible marginal bone loss can hinder recovery around dental implants. Insufficient alveolar osteogenesis and stress concentration during chewing contribute to marginal bone resorption and can result in implant failure. A biomaterial with a micropore-channel structure was developed using 3D printing technology. This design facilitated bony ingrowth and provided similar mechanical stimulation at the implant neck during mastication to a natural tooth. The micropore channels provided a guiding structure for bone mesenchymal stem cell proliferation and differentiation without the need for growth factors. Specifically, this was achieved through mechanical transduction by F-actin remodeling and the activation of Yes-associated protein (YAP). The implants were verified in a canine dental implant surgery model, which demonstrated the promising use of biomaterial-based dental implants in future clinical applications.