Role of the monocyte-macrophage in influenza virus infection of lymphocytes: implications for HIV infection.
Role of the monocyte-macrophage in influenza virus infection of lymphocytes: implications for HIV infection.
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单核细胞-巨噬细胞在流感病毒淋巴细胞感染中的作用：对 HIV 感染的影响。
DOI：
10.1089/aid.1990.6.965
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发表时间：
1990
影响因子：
1.5
通讯作者：
RobertsJr,NJ
中科院分区：
文献类型：
--
作者：
Mock,DJ;RobertsJr,NJ
了解毒性不如人类免疫缺陷病毒（HIV）的病毒的发病机制可能为了解HIV感染的发病机制提供有价值的见解。流感病毒是一种包膜RNA病毒，感染单核巨噬细胞，虽然感染是短暂的和流产的。分离纯化的淋巴细胞完全抵抗感染。相反，淋巴细胞和巨噬细胞的混合物可以合成所有的病毒蛋白。感染需要单核-巨噬细胞和淋巴细胞聚集在一起。这些对流感病毒的研究表明，混合细胞培养中病毒感染的发病机制可能与在纯化细胞群中观察到的发病机制大不相同，并建议对艾滋病毒进行类似的研究。
Knowledge of the pathogenesis of viruses which are less virulent than human immunodeficiency virus (HIV) may provide valuable insights into the pathogenesis of HIV infection. Influenza virus, an enveloped RNA virus, infects monocyte-macrophages, although the infection is brief and abortive. Isolated purified lymphocytes are completely resistant to infection. In contrast, mixtures of lymphocytes and macrophages can synthesize all virus proteins. Infection requires physical association of monocyte-macrophages and lymphocytes in "clusters." These studies with influenza virus suggest that the pathogenesis of virus infections in mixed cell cultures may be very different from that observed in purified cell populations, and they suggest that similar studies should be performed with HIV.