Surfactant-Impregnated MOF-Coated Fabric for Antimicrobial Applications.
Surfactant-Impregnated MOF-Coated Fabric for Antimicrobial Applications.
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DOI：
10.1021/acsabm.2c00860
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发表时间：
2023-01
影响因子：
4.7
通讯作者：
Gregory R. Schwenk;A. Glass;H. Ji;G. Ehrlich;S. Navas-Martín;Jarosław E. Król;Donald C. Hall
中科院分区：
文献类型：
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作者：
Gregory R. Schwenk;A. Glass;H. Ji;G. Ehrlich;S. Navas-Martín;Jarosław E. Król;Donald C. Hall
自SARS-CoV-2大流行爆发以来，全世界已有超过6.17亿确诊病例和超过654万确诊死亡病例，但实际总数可能要高得多。该病毒的变异速度比最初预测的要快得多，随着更多可传播变种的出现，阳性病例继续激增。根据疾控中心的说法，在提交本手稿时，目前美国所有病例中有77%以上是B.5(奥米克隆)的结果。高度可传播性变种的不断出现清楚地表明，需要更有效的方法来减缓疾病传播。在这里，我们开发了一种抗菌织物，能够摧毁包括贝塔冠状病毒在内的无数微生物。我们已经证明了这种高度多孔和无毒的金属有机骨架γ-CD-MOF-1作为不同长度的苯扎氯铵(BAC)的宿主的能力。分子对接模拟预测其结合亲和力高达-4.12kcal·mol-1，与其他已报道的MOF客体分子的结合亲和力相当。卸载和加载MOF之间相似的拉曼光谱和粉末X射线衍射图，伴随着Brunauer-Emmett-Teller表面积分别从616.20和155.55 m2·g-1下降，证实了BAC占据孔的可能性。MOF生长在丙纶织物上，暴露在负载BAC的浴缸中，洗涤以去除外表面多余的BAC，并评估其对各种细菌和病毒类别的杀菌活性。对铜绿假单胞菌、金黄色葡萄球菌、大肠杆菌、噬菌体和β冠状病毒有明显的抗菌作用。这项研究表明，一种常见的口罩材料(聚丙烯)可以在保持客体分子抗菌效果的同时，包覆负载γ-CD-MOF-1。
Since the onset of the SARS-CoV-2 pandemic, the world has witnessed over 617 million confirmed cases and more than 6.54 million confirmed deaths, but the actual totals are likely much higher. The virus has mutated at a significantly faster rate than initially projected, and positive cases continue to surge with the emergence of ever more transmissible variants. According to the CDC, and at the time of this manuscript submission, more than 77% of all current US cases are a result of the B.5 (omicron). The continued emergence of highly transmissible variants makes clear the need for more effective methods of mitigating disease spread. Herein, we have developed an antimicrobial fabric capable of destroying a myriad of microbes including betacoronaviruses. We have demonstrated the capability of this highly porous and nontoxic metal organic framework (MOF), γ-CD-MOF-1, to serve as a host for varied-length benzalkonium chlorides (BACs; active ingredient in Lysol). Molecular docking simulations predicted a binding affinity of up to -4.12 kcal·mol-1, which is comparable to that of other reported guest molecules for this MOF. Similar Raman spectra and powder X-ray diffraction patterns between the unloaded and loaded MOFs, accompanied by a decrease in the Brunauer-Emmett-Teller surface area from 616.20 and 155.55 m2 g-1 respectively, corroborate the suggested potential for pore occupation with BAC. The MOF was grown on polypropylene fabric, exposed to a BAC-loading bath, washed to remove excess BAC from the external surface, and evaluated for its microbicidal activity against various bacterial and viral classes. Significant antimicrobial character was observed against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, bacteriophage, and betacoronavirus. This study shows that a common mask material (polypropylene) can be coated with BAC-loaded γ-CD-MOF-1 while maintaining the guest molecule's antimicrobial effects.