Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora
Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora
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DOI：
10.1055/s-2006-957692
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发表时间：
1997-08-01
期刊：
影响因子：
2.7
通讯作者：
Cheng, JT
中科院分区：
文献类型：
--
作者：
Hsu, FL;Lai, CW;Cheng, JT
芍药苷和8-脱苯甲酰芍药苷是从芍药的干燥根中分离得到的。（毛茛科）。它们在链脲佐菌素处理的大鼠中产生显著的血糖降低效果，并且在处理后25分钟具有最大效果。仅在1 mg/kg剂量下，在血糖正常大鼠中也观察到这种降血糖作用。8-脱苯甲酰芍药苷的降血糖活性似乎低于芍药苷。芍药苷治疗血糖正常大鼠的血浆胰岛素没有变化，表明胰岛素非依赖性作用。此外，这种葡萄糖苷降低了葡萄糖激发大鼠的血糖升高。因此可以认为芍药苷增加了葡萄糖的利用。没有先前的数据显示芍药苷和/或8-脱苯甲酰芍药苷在大鼠中的降血糖活性。
Paeoniflorin and 8-debenzoylpaeoniflorin were isolated from the dried root of Paeonio lactiflora Pall. (Ranunculaceae). They produced a significant blood sugar lowering effect in streptozotocin-treated rats and had a maximum effect at 25 min after treatment. This hypoglycemic action was also observed in normoglycemic rats only at 1 mg/kg. The antihyperglycemic activity of 8-debenzoylpaeoniflorin seems lower than that of paeoniflorin. Plasma insulin was not changed in paeoniflorin-treated normoglycemic rats indicating an insulin-independent action. Also, this glucoside reduced the elevation of blood sugar in glucose challenged rats. Increase of glucose utilization by paeoniflorin can thus be considered. There are no previous data showing the hypoglycemic activity of paeoniflorin and/or 8-debenzoylpaeoniflorin in rats.