Concomitant Use of Prescription Drugs and Dietary Supplements in Ambulatory Elderly People
Concomitant Use of Prescription Drugs and Dietary Supplements in Ambulatory Elderly People
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DOI：
10.1111/j.1532-5415.2009.02329.x
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发表时间：
2009-07-01
影响因子：
6.3
通讯作者：
Fitzpatrick, Annette L.
中科院分区：
文献类型：
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作者：
Nahin, Richard L.;Pecha, Monica;Fitzpatrick, Annette L.
目的分析银杏记忆评价（GEM）研究中老年人同时使用处方药和膳食补充剂的基线数据，该研究收集了参与者使用的所有药物和补充剂的信息。参与者3070例年龄在75岁及以上的门诊患者于2000年9月至2002年6月期间入组。几乎四分之三（74.2%）的队列组合使用至少一种处方药和一种膳食补充剂，32.5%使用三种或更多种处方药和三种或更多种补充剂。15种最常见的处方药与膳食补充剂大量合并使用，范围从利尿剂的77.6%到雌激素制剂的93.6%。虽然补充剂与所有类别的处方药同时服用，但补充剂的使用更可能发生在使用非甾体抗炎药、甲状腺药物和雌激素的个体中。糖尿病药物的使用与补充剂的使用呈负相关，其中大部分归因于低使用在那些服用多种维生素，葡萄糖胺和软骨素，和echinacea.CONCLUSION有大量的处方药和膳食补充剂在老年人的伴随使用。需要进一步的研究来确定这种伴随使用的临床重要性，特别是在服用多种处方药或发生继发于处方药的不良事件的老年患者中。
OBJECTIVESTo analyze baseline data on concomitant use of prescription drugs and dietary supplements in elderly people from the Ginkgo Evaluation of Memory (GEM) Study, in which information was collected on all drugs and supplements used by participant.DESIGNCross-sectional correlation analysis.SETTINGGEM Study sites in California, Maryland, North Carolina, and Pennsylvania.PARTICIPANTSThree thousand seventy ambulatory individuals aged 75 and older enrolled between September 2000 and June 2002.MEASUREMENTSUse of prescription drugs and dietary supplements identified through bottles brought to the clinic.RESULTSAlmost three-quarters (74.2%) of the cohort combined use of at least one prescription drug and one dietary supplement, with 32.5% using three or more prescription drugs and three or more supplements. The 15 most-prevalent prescription drugs exhibited substantial concomitant use with dietary supplements, ranging from 77.6% for diuretics to 93.6% for estrogen preparations. Although supplements were taken concomitantly with all classes of prescription drugs, the use of supplements was more likely in individuals using nonsteroidal anti-inflammatory drugs, thyroid drugs, and estrogens. The use of drugs for diabetes mellitus was negatively associated with the use of supplements, with most of this attributed to low use in those taking multivitamins, glucosamine and chondroitin, and echinacea.CONCLUSIONThere is substantial concomitant use of prescription drugs and dietary supplements in elderly people. Further investigations are needed to define the clinical importance of this concomitant use, especially in elderly patients who consume multiple prescription drugs or have experienced an adverse event secondary to their prescription medications.