Neurocognitive correlates of child obsessive compulsive disorder and Tourette syndrome
Neurocognitive correlates of child obsessive compulsive disorder and Tourette syndrome
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DOI：
10.1080/13825580600966383
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发表时间：
2007-01-01
影响因子：
2.2
通讯作者：
Piacentini, John C.
中科院分区：
文献类型：
--
作者：
Chang, Susanna W.;McCracken, James T.;Piacentini, John C.
这项研究调查了儿童强迫症和TS的神经认知相关性，据称这两种疾病都有额叶-纹状体功能障碍。对三组受试者进行神经认知测量，包括执行、注意力/记忆和视觉运动能力等额纹状体功能，无共病强迫症(OCD)的强迫症(OCD)，无共患强迫症(TS)的TS(TS)和正常对照组。结果表明，强迫症组与健康对照组相比，在空间注意领域表现出缺陷。与TS组相比，强迫症参与者没有表现出认知缺陷。与强迫症和正常对照组相比，TS参与者在反应抑制、注意力分散和认知灵活性方面显示出损害的趋势。强迫症组的空间注意力缺陷与成人强迫症研究部分一致，表明空间记忆缺陷。TS的发现不那么可靠，可以暂时解释为提示执行功能缺陷。需要进一步的研究来描述发育对与强迫症和TS相关的神经认知障碍的影响。
This study investigated the neurocognitive correlates of childhood OCD and TS, which are purported to share frontal-striatal dysfunction. Neurocognitive measures tapping frontal-striatal functions such as executive, attention/memory, and visuomotor abilities were administered to three groups of participants, OCD without comorbid TS (OCD), TS without comorbid OCD (TS), and normal controls. Results suggested that OCD group demonstrated deficits in the area of spatial attention relative to healthy controls. The OCD participants demonstrated no cognitive deficits compared to the TS group. TS participants showed trends towards impairments in the areas of response inhibition, divided attention, and cognitive flexibility relative to the OCD and normal control groups. Spatial attention deficits for the OCD group are partially consistent with adult OCD studies indicating deficits in spatial memory. TS findings were less robust and may be construed tentatively as suggestive of executive function deficits. Future research is needed to delineate the influence of development on neurocognitive deficits associated with OCD and TS.