Fusion and fission pathways of vesicles from amphiphilic triblock copolymers: a dissipative particle dynamics simulation study
Fusion and fission pathways of vesicles from amphiphilic triblock copolymers: a dissipative particle dynamics simulation study
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两亲性三嵌段共聚物囊泡的融合和裂变途径：耗散粒子动力学模拟研究
DOI：
10.1039/b817773b
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发表时间：
2009-01-01
影响因子：
3.3
通讯作者：
Liang, Haojun
中科院分区：
文献类型：
--
作者：
Li, Xuejin;Liu, Yuan;Liang, Haojun
采用耗散粒子动力学（DPD）方法研究了两亲性三嵌段共聚物形成的聚合物囊泡的融合和分裂动力学。两亲性分子由两个亲水性嵌段和一个疏水性中间嵌段构成。在模拟过程中发现了两种不同的途径的聚合物基对称膜的两组分囊泡的融合和分裂过程。对于每一个途径，获得完全聚变和裂变所需的条件进行了研究。此外，在模拟中还研究了单组分囊泡与聚合物基非对称膜的分裂过程。有趣的是，子囊泡具有与父囊泡相同的组成，并且仅观察到一个裂变途径。此外，融合和分裂的途径进行了比较，不同的囊泡回收途径已建议根据模拟的结果。这些发现可能有助于解释囊泡的融合和分裂动力学以及理解膜的一般原理。
Dissipative particle dynamics (DPD) simulations are employed to study the fusion and fission dynamics of polymeric vesicles formed from amphiphilic triblock copolymers. The amphiphilic molecule is built from two hydrophilic blocks and a hydrophobic middle block. Two different pathways for both fusion and fission processes of two-component vesicles with polymer-based symmetric membranes have been found in the simulations. For each of the pathways, the conditions required to obtain complete fusion and fission have been investigated. Moreover, the fission process of single-component vesicles with polymer-based asymmetric membranes has also been studied in the simulations. Interestingly, the daughter vesicles have the same composition as the parent vesicle and only one fission pathway has been observed. Furthermore, the fusion and fission pathways have been compared and distinct vesicle recycling pathways have been suggested according to the results from the simulations. These findings may be helpful in explaining the fusion and fission dynamics of vesicles and understanding the general principle of membranes.