Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State
Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State
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精神状态高危个体的皮层下脑容量异常
DOI：
10.1093/schbul/sbaa011
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发表时间：
2020
影响因子：
6.6
通讯作者：
Matsumoto Kazunori
中科院分区：
文献类型：
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作者：
Sasabayashi Daiki;Takayanagi Yoichiro;Takahashi Tsutomu;Katagiri Naoyuki;Sakuma Atsushi;Obara Chika;Katsura Masahiro;Okada Naohiro;Koike Shinsuke;Yamasue Hidenori;Nakamura Mihoko;Furuichi Atsushi;Kido Mikio;Nishikawa Yumiko;Noguchi Kyo;Matsumoto Kazunori
以前的结构磁共振成像研究精神病性障碍已经证明了皮质下（即基底神经节，丘脑）和颞叶边缘结构的体积改变，这涉及高阶认知和情绪调节。然而，目前尚不清楚是否有精神病性障碍的高风险个体在这些区域表现出体积变化，药物的混杂作用最小。这项多中心磁共振成像研究评估了丘脑，尾状核，壳核，丘脑，苍白球，海马和杏仁核的区域体积，以及侧脑室体积，使用FreeSurfer软件在107名患有危险精神状态（ARMS）的个体中进行（其中21人[19.6%]在临床随访期间[平均= 4.9年，SD = 2.6年]后来发展为精神病）和在4个不同地点招募的104名年龄和性别匹配的健康对照。ARMS个体作为一个整体表现出显着更大的体积为左侧尾状核和双侧侧脑室，以及一个较小的体积为右侧脑桥与对照组相比。仅在男性受试者中，ARMS个体的左侧苍白球显著较大。ARMS组的特征还在于侧脑室和尾状核的左大于右不对称。有和没有较晚精神病发作的ARMS组之间的区域体积没有显着差异。本研究表明，侧脑室，尾状核和苍白球的显着体积扩张，以及体积减少的ARMS受试者，这不能解释的药物作用，可能与一般的脆弱性，精神病理学。
Previous structural magnetic resonance imaging studies of psychotic disorders have demonstrated volumetric alterations in subcortical (ie, the basal ganglia, thalamus) and temporolimbic structures, which are involved in high-order cognition and emotional regulation. However, it remains unclear whether individuals at high risk for psychotic disorders with minimal confounding effects of medication exhibit volumetric changes in these regions. This multicenter magnetic resonance imaging study assessed regional volumes of the thalamus, caudate, putamen, nucleus accumbens, globus pallidus, hippocampus, and amygdala, as well as lateral ventricular volume using FreeSurfer software in 107 individuals with an at-risk mental state (ARMS) (of whom 21 [19.6%] later developed psychosis during clinical follow-up [mean = 4.9 years, SD = 2.6 years]) and 104 age- and gender-matched healthy controls recruited at 4 different sites. ARMS individuals as a whole demonstrated significantly larger volumes for the left caudate and bilateral lateral ventricles as well as a smaller volume for the right accumbens compared with controls. In male subjects only, the left globus pallidus was significantly larger in ARMS individuals. The ARMS group was also characterized by left-greater-than-right asymmetries of the lateral ventricle and caudate nucleus. There was no significant difference in the regional volumes between ARMS groups with and without later psychosis onset. The present study suggested that significant volume expansion of the lateral ventricle, caudate, and globus pallidus, as well as volume reduction of the accumbens, in ARMS subjects, which could not be explained only by medication effects, might be related to general vulnerability to psychopathology.