Methylphenidate effects on symptoms of attention deficit disorder in adults.
Methylphenidate effects on symptoms of attention deficit disorder in adults.
复制标题
哌醋甲酯对成人注意力缺陷障碍症状的影响。
DOI：
10.1001/archpsyc.1983.01790220049008
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发表时间：
1984
影响因子：
--
通讯作者：
H. Oliver
中科院分区：
文献类型：
--
作者：
J. Mattes;L. Boswell;H. Oliver
本研究的目的是：（1）确定注意缺陷障碍（ADD）是否是成年人的一种特异性诊断实体;（2）采用双盲交叉设计，评价盐酸哌甲酯对有残留ADD伴多动（ADD-H）证据的成年人（N = 26）的疗效;（3）对有类似成人症状但无儿童期ADD-H病史的患者（N = 35）也给予哌醋甲酯，以评价药物反应的特异性。结果表明，成功区分了相对不同的群体。然而，无论儿童是否有ADD-H病史，哌醋甲酯的总体益处都不明显。大约25%的样本出现临床受益于哌甲酯，但没有明确的预测药物反应被确定;药物滥用史（多种药物）似乎是最好的预测。即使在应答者中，获益通常也不像儿童ADD-H那样显著，也不像儿童ADD-H那样具有临床价值。
The objectives of this study were (1) to determine whether attention deficit disorder (ADD) is a specific diagnostic entity in adulthood; (2) to evaluate, using a double-blind crossover design, the efficacy of methylphenidate hydrochloride in adults with evidence of residual ADD with hyperactivity (ADD-H) (N = 26); and (3) to evaluate the specificity of drug response by also administering methylphenidate to patients with similar adult symptoms but no childhood history of ADD-H (N = 35). Results indicated success in differentiating relatively distinct groups. However, no overall benefit from methylphenidate was evident, regardless of childhood history of ADD-H. Approximately 25% of the sample appeared clinically to benefit from methylphenidate, but no clear-cut predictors of drug response were identified; history of drug abuse (polydrug) appeared to be the best predictor. Even among the responders, benefit was generally not as marked nor as clinically valuable as in childhood ADD-H.