Pathophysiology of Myocardial Injury and Remodeling: Implications for Molecular Imaging
Pathophysiology of Myocardial Injury and Remodeling: Implications for Molecular Imaging
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DOI：
10.2967/jnumed.109.068213
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发表时间：
2010-05-01
影响因子：
9.3
通讯作者：
Spinale, Francis G.
中科院分区：
文献类型：
--
作者：
Dixon, Jennifer A.;Spinale, Francis G.
尽管再灌注治疗取得了进展，急性冠状动脉综合征仍可导致心肌损伤和随后的心肌梗死（MI）。急性心肌梗死前的分子、细胞和间质性事件最终导致左心室（LV）大小、形状和功能的有害改变，统称为左心室重构。在心肌梗死后，可以描述三个不同的解剖和生理左室区域：梗死区、边界区和远端区。考虑到心肌梗死后重构的复杂性，成像方式必须同样多样化，以阐明这一过程。本综述的重点将首先放在心肌梗死后重构过程的自然历史中最感兴趣的左室解剖和病理生理区域的心血管MRI。这篇综述将研究成像模式，为心肌梗死后重构衰减的新兴治疗领域提供翻译和分子见解，如心脏约束装置和干细胞治疗。
Despite advances in reperfusion therapy, acute coronary syndromes can still result in myocardial injury and subsequent myocardial infarction (MI). Molecular, cellular, and interstitial events antecedent to the acute MI culminate in deleterious changes in the size, shape, and function of the left ventricle (LV), collectively termed LV remodeling. Three distinct anatomic and physiologic LV regions can be described after MI: the infarct, border zone, and remote regions. Given the complexity of post-MI remodeling, imaging modalities must be equally diverse to elucidate this process. The focus of this review will first be on cardiovascular MRI of the anatomic and pathophysiologic LV regions of greatest interest with regard to the natural history of the post-MI remodeling process. This review will then examine imaging modalities that provide translational and molecular insight into burgeoning treatment fields for the attenuation of post-MI remodeling, such as cardiac restraint devices and stem cell therapy.