Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study.
Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study.
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DOI：
10.1161/circulationaha.108.772822
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发表时间：
2008-07-22
期刊：
影响因子：
37.8
通讯作者：
Wisløff U
中科院分区：
文献类型：
--
作者：
Tjønna AE;Lee SJ;Rognmo Ø;Stølen TO;Bye A;Haram PM;Loennechen JP;Al-Share QY;Skogvoll E;Slørdahl SA;Kemi OJ;Najjar SM;Wisløff U
患有代谢综合征的人死于心脏病的可能性是健康人的三倍。运动训练可以减轻该综合征的几种症状，但哪种运动强度能产生最大的有益适应是有争议的。我们比较了中、高运动强度与代谢综合征患者心血管功能和预后相关的变量。32例代谢综合征患者（52.3±3.7岁，最大摄氧量（VO 2 max）34 ml/kg/min）随机分为中等强度连续训练组（CME，最高心率的70%; Hfmax）、有氧间歇训练组（AIT，Hfmax的90%）或对照组，每周3次，持续16周。与CME相比，AIT后VO 2 max增加更多（35% vs. 16%，p<0.01），并且与消除构成代谢综合征的更多风险因素相关（AIT中的因素数量：5.9前vs. 4.0后，（p<0.01）; CME：5.7前vs. 5.0后，组间差异p<0.05）。与CME相比，AIT在增强内皮功能（9%对5%，p<0.001）、脂肪和骨骼肌中的胰岛素信号传导、骨骼肌生物发生和兴奋-收缩偶联以及降低血糖和脂肪组织中的脂肪生成方面上级CME。这两种锻炼计划在降低平均动脉血压和减轻体重（AIT和CME分别为-2.3和-3.6公斤）和脂肪方面同样有效。运动强度是改善有氧能力、逆转代谢综合征危险因素的重要因素。这些发现可能对康复计划中的运动训练和未来的研究具有重要意义。
Individuals with the metabolic syndrome are three times more likely to die from heart disease than healthy counterparts. Exercise-training reduces several of the symptoms of the syndrome, but which exercise-intensity that yields maximal beneficial adaptations is controversial. We compared moderate to high exercise-intensity with regard to variables associated with cardiovascular function and prognosis in patients with the metabolic syndrome. Thirty-two metabolic syndrome patients (52.3±3.7 yrs, maximal oxygen uptake (VO2max) 34 ml/kg/min) were randomized to equal volumes of either moderate continuous-training (CME at 70% of highest measured heart rate; Hfmax), aerobic interval-training (AIT at 90% of Hfmax) 3-times/week for 16-weeks, or to a control group. VO2max increased more after AIT vs. CME (35% vs. 16%, p<0.01) and was associated with removal of more risk factors that constitute the metabolic syndrome (Number of factors in AIT: 5.9 pre vs. 4.0 post, (p<0.01); CME: 5.7 pre vs. 5.0 post, group difference p<0.05). AIT was superior compared to CME in enhancing endothelial function (9% vs. 5%, p<0.001), insulin signaling in fat and skeletal muscle, skeletal muscle biogenesis and excitation-contraction coupling, and reducing blood glucose and lipogenesis in adipose tissue. The two exercise-programs were equally effective at lowering mean arterial blood pressure and reducing body weight (−2.3 and −3.6 kg in AIT and CME, respectively) and fat. Exercise-intensity was an important factor for improving aerobic capacity and reversing the risk factors of the metabolic syndrome. These findings may have important implications for exercise training in rehabilitation programs and future studies.