Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China
Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China
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基因表达和临床变量的生物学分析表明 FZD1 可作为中国流行的骨关节炎大骨节病患者的新型生物标志物
DOI：
10.1155/2019/3736198
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Guo Xiong
中科院分区：
文献类型：
--
作者：
Wang Xi;Ning Yujie;Zhang Pan;Yang Lei;Li Cheng;Zhou Rong;Guo Xiong
临床变量有助于大骨节病（KBD）的严重程度。然而，目前尚不清楚基因表达和临床变量之间是否存在相关性。收集100例大骨节病患者和100例健康对照者的外周血样本，筛选大骨节病患者和健康对照者的差异表达基因。相关分析和多元Logistic回归分析使用基因表达和临床参数。免疫组化法检测关节软骨组织中相关蛋白的表达。在大骨节病患者中发现了39个差异表达基因。9个差异表达基因与掌骨长/掌骨宽指数相关。FZD 1在建立临床参数与基因表达的回归模型中具有统计学意义。大骨节病患者FZD 1表达水平显著降低。我们的研究结果表明，FZD 1可能参与了指骨粗隆和短指的病理过程，并可能提供新的见解，观察大骨节病患者关节软骨破坏的发病机制。
Clinical variables contribute to the severity of Kashin-Beck disease (KBD). However, it is unclear if there is a correlation between gene expression and clinical variables. Peripheral blood samples were collected from 100 patients with KBD and 100 healthy controls from KBD-endemic areas to identify differentially expressed genes in KBD. Correlation analysis and multiple logistic regression analysis were performed using gene expression and clinical parameters. Immunohistochemistry (IHC) was used to detect the expression of related proteins in articular cartilage tissues. Thirty-nine differentially expressed genes were identified in patients with KBD. Nine differentially expressed genes were correlated with the metacarpal length/metacarpal breadth index. FZD1 was identified as having statistical significance in establishing the regression model of clinical parameters and gene expression. FZD1 expression levels were remarkably reduced in patients with KBD. Our results indicate that FZD1 could be involved in the pathological process of phalanges tuberositas and brachydactylia and may provide new insight into the pathogenesis of articular cartilage destruction observed in patients with KBD.
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影响因子：
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作者：
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