Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking
Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking
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DOI：
10.1016/j.ijrobp.2007.05.072
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发表时间：
2007-01-01
影响因子：
7
通讯作者：
Carey, Thomas E.
中科院分区：
文献类型：
--
作者：
Kumar, Bhavna;Cordell, Kitrina G.;Carey, Thomas E.
有效的诱导化疗和同步放化疗或无效的立即手术是治疗喉部和口咽部头颈部鳞状细胞癌的有效策略。预测结果的生物标志物在选择接受治疗的患者时将是有价值的。本研究检测了参加器官保留试验的口咽癌患者治疗前活检组织中高危型人乳头瘤病毒(HPV)的存在和滴度，表皮生长因子受体(EGFR)的表达，以及吸烟和性别。在多因素分析中，HPV16拷贝数与治疗反应、总生存率和疾病特异性生存率呈正相关，而EGFR表达、现在或以前吸烟行为和女性(在该队列中)与不良反应和低生存率相关。戒烟和靶向EGFR的策略可能是治疗的有用辅助手段，以改善生物标志物特征最差的病例的结果。(C)2007年爱思唯尔公司。
Induction chemotherapy and concurrent chemoradiation for responders or immediate surgery for non-responders is an effective treatment strategy head and neck squamous cell carcinoma (HNSCC) of the larynx and oropharynx. Biomarkers that predict outcome would be valuable in selecting patients for therapy. In this study, the presence and titer of high risk human papilloma virus (HPV) and expression of epidermal growth factor receptor (EGFR) in pre-treatment biopsies, as well as smoking and gender were examined in oropharynx cancer patients enrolled in an organ sparing trial. HPV16 copy number was positively associated with response to therapy and with overall and disease specific survival, whereas EGFR expression, current or former smoking behavior, and female gender (in this cohort) were associated with poor response and poor survival in multivariate analysis. Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile. (C) 2007 Elsevier Inc.