Influence of acute exercise on hyperglycemia in insulin-treated type 2 diabetes
Influence of acute exercise on hyperglycemia in insulin-treated type 2 diabetes
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DOI：
10.1249/01.mss.0000235352.09061.1d
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发表时间：
2006-12-01
期刊：
影响因子：
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通讯作者：
Van Loon, Luc J.
中科院分区：
文献类型：
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作者：
Praet, Stephan F.;Manders, Ralph J.;Van Loon, Luc J.
在长期接受外源性胰岛素治疗的2型糖尿病患者中，尚未评估运动对血糖稳态的影响。目的：研究胰岛素治疗的2型糖尿病患者在自由生活条件下，急性运动对随后24小时血糖漂移的影响。方法：11例男性2型糖尿病患者（59 2岁）进行急性运动。运动前一天，在脐周皮下植入连续血糖监测系统（GlucoDay (R), a . Menarini Diagnostics）。葡萄糖传感器在48小时内连续测量透析液中的葡萄糖浓度。结果：急性运动后24小时（相当于3小时）内高血糖漂移的发生率降低39% （P < 0.05）。运动前后24 h平均葡萄糖浓度无差异（NS）。平均透析液葡萄糖浓度和高血糖期的发生率与基线血液HbA(1)c浓度密切相关（Pearson’s R = 0.69, P < 0.05）。结论：急性运动可有效降低长期接受外源性胰岛素治疗的2型糖尿病患者在自由生活条件下24小时内高血糖的发生率。
Introduction: The impact of exercise on blood glucose homeostasis has not been assessed in long-standing type 2 diabetes patients receiving exogenous insulin treatment. Purpose: To study the effects of an acute bout of exercise on the subsequent 24-h blood glucose excursions under free-living conditions in insulin-treated type 2 diabetes patients. Methods: Eleven male type 2 diabetes patients (59 2 yr) performed an acute bout of exercise. One day before the exercise bout, a continuous glucose monitoring system (GlucoDay (R), A. Menarini Diagnostics) was inserted subcutaneously in the periumbilical region. The glucose sensor continuously measured glucose concentrations in the dialysate during a 48-h period. Results: The prevalence of hyperglycemic glucose excursions was reduced by 39% during a 24-h period (equivalent to 3 h) after an acute bout of exercise (P < 0.05). Average glucose concentrations 24 h before and after the exercise bout did not differ (NS). Mean dialysate glucose concentrations and the prevalence of hyperglycemic periods correlated strongly with baseline blood HbA(1)c concentrations (Pearson's R = 0.69, P < 0.05). Conclusion: An acute bout of exercise effectively reduces the prevalence of hyperglycemia during a 24-h period under free-living conditions in long-standing type 2 diabetes patients on exogenous insulin therapy.