Integrative assessment of brain function in PTSD: brain stability and working memory.
Integrative assessment of brain function in PTSD: brain stability and working memory.
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DOI：
10.1142/s0219635206001057
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发表时间：
2006-03
影响因子：
1.8
通讯作者：
Melinda D. Veltmeyer;Alexander C. McFarlane;Richard A. Bryant;T. Mayo;E. Gordon;C. Clark
中科院分区：
文献类型：
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作者：
Melinda D. Veltmeyer;Alexander C. McFarlane;Richard A. Bryant;T. Mayo;E. Gordon;C. Clark
创伤后应激障碍（PTSD）的特征是过度觉醒、回避和侵入性创伤相关记忆以及日常记忆和注意力缺陷的症状。对创伤后应激障碍的单独研究发现，脑电图、事件相关电位（ERP）以及工作记忆和注意力的行为测量都存在异常。本研究旨在确定这些异常是否相关，以及它们与临床症状之间的关系。EEG数据收集过程中的睁眼范例和一回工作记忆任务。还收集了行为和临床数据（CAPS）。创伤后应激障碍组表现出改变的皮质唤醒的迹象，其指标为α功率降低和θ/α比率增加，并且发现唤醒的临床和生理测量是相关的。在PTSD中，θ功率和工作记忆ERP指数之间的正常关系没有受到影响，两组指标在紊乱组中均降低。药物似乎支持一些异常参数，包括P3振幅的目标和准确性，但不是速度，目标检测。本研究有助于克服早期研究的局限性，这些研究在不同的患者群体中独立评估这些参数，这些患者群体在合并症、药物治疗状态、性别和症状特征等因素上各不相同。本研究开始阐明这些措施之间的关系，并表明大脑工作记忆的异常可能与大脑稳定性的潜在异常有关。
Posttraumatic Stress Disorder (PTSD) is characterized by symptoms of hyperarousal, avoidance and intrusive trauma-related memories and deficits in everyday memory and attention. Separate studies in PTSD have found abnormalities in electroencephalogram EEG, in event-related potential (ERP) and behavioral measures of working memory and attention. The present study seeks to determine whether these abnormalities are related and the extent to which they share this relationship with clinical symptoms. EEG data were collected during an eyes-open paradigm and a one-back working memory task. Behavioral and clinical data (CAPS) were also collected. The PTSD group showed signs of altered cortical arousal as indexed by reduced alpha power and an increased theta/alpha ratio, and clinical and physiological measures of arousal were found to be related. The normal relationship between theta power and ERP indices of working memory was not affected in PTSD, with both sets of measures reduced in the disordered group. Medication appeared to underpin a number of abnormal parameters, including P3 amplitude to targets and the accuracy, though not speed, of target detection. The present study helps to overcome a limitation of earlier studies that assess such parameters independently in different groups of patients that vary in factors such as comorbidity, medication status, gender and symptom profile. The present study begins to shed light on the relationship between these measures and suggests that abnormalities in brain working memory may be linked to underlying abnormalities in brain stability.