Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment
Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment
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DOI：
10.1046/j.1523-1747.2001.01238.x
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发表时间：
2001-02-01
影响因子：
6.5
通讯作者：
Hirao, T
中科院分区：
文献类型：
--
作者：
Ashida, Y;Denda, M;Hirao, T
角质形成细胞具有组胺H-1和H-2受体，但其功能知之甚少。为了阐明组胺受体在表皮中的作用，我们研究了组胺受体拮抗剂和激动剂应用epicuphilic对无毛小鼠的皮肤屏障功能的恢复被胶带剥离破坏的影响。组胺H-2受体拮抗剂法莫替丁和西咪替丁促进皮肤屏障功能的恢复，而组胺和组胺H-2受体激动剂二甲双胍则延迟屏障修复。应用化合物48/80（一种组胺释放剂）也延迟了恢复。咪唑，组胺的类似物，没有效果。组胺H-1受体拮抗剂苯海拉明和曲吡那明可加速恢复。组胺H-3受体激动剂N-α-甲基组胺和拮抗剂硫代哌丁胺无影响。此外，局部应用法莫替丁或苯海拉明可防止干燥环境（潮湿）中丙酮处理破坏皮肤屏障的小鼠的表皮增生
Keratinocytes have histamine H-1 and H-2 receptors, but their functions are poorly understood. To clarify the role of histamine receptors in the epidermis, we examined the effects of histamine receptor antagonists and agonists applied epicutaneously on the recovery of skin barrier function disrupted by tape stripping in hairless mice. Histamine H-2 receptor antagonists famotidine and cimetidine accelerated the recovery of skin barrier function, but histamine and histamine H-2 receptor agonist dimaprit delayed the barrier repair. Application of compound 48/80, a histamine releaser, also delayed the recovery. Imidazole, an analog of histamine, had no effect. The histamine H-1 receptor antagonists diphenhydramine and tripelennamine accelerated the recovery. Histamine H-3 receptor agonist N-alpha-methylhistamine and antagonist thioperamide had no effect. In addition, topical application of famotidine or diphenhydramine prevented epidermal hyperplasia in mice with skin barrier disrupted by acetone treatment in a dry environment (humidity