Palladium-catalyzed sequential carbon-carbon bond cleavage/formation producing arylated benzolactones.
Palladium-catalyzed sequential carbon-carbon bond cleavage/formation producing arylated benzolactones.
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DOI：
10.1021/ol802218a
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发表时间：
2008-10
期刊：
影响因子：
5.2
通讯作者：
T. Matsuda;Masanori Shigeno;M. Murakami
中科院分区：
文献类型：
--
作者：
T. Matsuda;Masanori Shigeno;M. Murakami
3-(2-羟基苯基)环丁酮与芳基溴在钯催化剂存在下反应，通过涉及碳-碳键断裂和形成的序列以高产率提供4-芳基甲基-3,4-二氢香豆素。在与2-(2-羟基苯基)环丁酮反应的情况下，根据2-位上是否存在额外的取代基，生成五元或七元内酯。
3-(2-Hydroxyphenyl)cyclobutanones react with aryl bromides in the presence of palladium catalysts to afford 4-arylmethyl-3,4-dihydrocoumarins in high yields through a sequence involving carbon-carbon bond cleavage and formation. In the case of the reaction with 2-(2-hydroxyphenyl)cyclobutanones, five- or seven-membered lactones were produced depending on the presence of an additional substituent at the 2-position.