Sensitivity study of x-ray luminescence computed tomography.
Sensitivity study of x-ray luminescence computed tomography.
复制标题
DOI：
10.1364/ao.56.003010
复制
发表时间：
2017-04-10
期刊：
影响因子：
1.9
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Lun MC;Zhang W;Li C
X射线发光计算机断层扫描（XLCT）是一种混合分子成像模式，结合了X射线成像（高分辨率）和光学成像（高灵敏度）的优点。在这项研究中，我们评估了XLCT的灵敏度与幻影实验扫描目标的不同浓度的磷在不同的深度。我们发现，XLCT能够在显著深度（如21 mm）对极低浓度（27.6 μM或0.01 mg/mL）的靶进行成像。我们的结果表明，XLCT重建的靶尺寸变化很小，不同成像深度的最大靶尺寸误差为4.35%。我们第一次比较了XLCT与传统计算机断层扫描（CT）对荧光靶的灵敏度。我们发现，与仅基于X射线衰减提供图像对比度的CT相比，XLCT使用X射线诱导光子提供了更高的测量灵敏度和对比度。
X-ray luminescence computed tomography (XLCT) is a hybrid molecular imaging modality that combines the merits of both x-ray imaging (high resolution) and optical imaging (high sensitivity). In this study, we have evaluated the sensitivity of XLCT with phantom experiments by scanning targets of different phosphor concentrations at different depths. We found that XLCT is capable of imaging targets of very low concentrations (27.6 μM or 0.01 mg/mL) at significant depths, such as 21 mm. Our results demonstrate that there is little variation in the reconstructed target size with a maximum target size error of 4.35% for different imaging depths for XLCT. We have for the first time, compared the sensitivity of XLCT with that of traditional computed tomography (CT) for phosphor targets. We found that XLCT’s use of x-ray induced photons provides much higher measurement sensitivity and contrast compared to CT which provides image contrast solely based on x-ray attenuation.