Depression of natural killer cytotoxicity after in vivo administration of recombinant leukocyte interferon.
Depression of natural killer cytotoxicity after in vivo administration of recombinant leukocyte interferon.
复制标题
体内施用重组白细胞干扰素后自然杀伤细胞毒性的抑制。
DOI：
10.4049/jimmunol.131.1.503
复制
发表时间：
1983
影响因子：
4.4
通讯作者：
R. Herberman
中科院分区：
文献类型：
--
作者：
A. Maluish;J. Ortaldo;J. Conlon;S. Sherwin;R. Leavitt;D. Strong;P. Weirnik;R. Oldham;R. Herberman
对134例多种恶性肿瘤患者进行了两期重组白细胞A型干扰素临床试验。IFL-Ra每天2次或每周3次肌肉注射，共28天。对这些患者进行了广泛的自然杀伤(NK)细胞毒性监测，采用了严格标准化的检测方法，并确定了每个患者NK功能的内在变异性。在这两种治疗方案中使用的干扰素未能显著增加NK活性；在大多数患者中，NK活性与治疗前基线水平相比没有显著变化。一个意想不到的发现是，30%的患者NK活性下降。对这些数据进行了分析，分析了它们与IFL-Ra给药剂量和给药时间表以及抗肿瘤反应的可能关系。
One hundred thirty-four patients with a variety of malignancies were treated in two phase I clinical trials of recombinant leukocyte A interferon (IFL-rA) produced by recombinant DNA methodology. IFL-rA was given by intra-muscular injection either twice daily or three times weekly for 28 days. Extensive monitoring of natural killer (NK) cell cytotoxicity was done on these patients with rigorously standardized assays and determination of the inherent variability of NK function for each individual. Interferon, as used in these two treatment regimens, failed to produce an appreciable increase in NK activity; in the majority of patients, there was no significant change in NK activity from the pretreatment baseline levels. An unexpected finding was the depression of NK activity in 30% of the patients. The data have been analyzed in terms of their possible relationship to dose and schedules of IFL-rA administration and to antitumor response.