Minute gastric adenocarcinoma of the fundic-gland type with submucosal invasion.
Minute gastric adenocarcinoma of the fundic-gland type with submucosal invasion.
复制标题
胃底腺型微小胃腺癌，伴有粘膜下浸润。
DOI：
10.1055/a-1625-5865
复制
发表时间：
2022
期刊：
影响因子：
9.3
通讯作者：
Nagahara A.
中科院分区：
文献类型：
--
作者：
Takeda T;Ueyama H;Fu KI;Murata S;Nagahara A.
一名64岁女性，无幽门螺杆菌感染，在健康检查期间接受了食管胃镜检查。在胃底大弯处检测到一个2 mm的扁平病变（0-IIb），颜色褪色，集合小静脉排列规则。窄带成像（NBI）显示明显的白色病变。NBI放大内镜显示规则的微表面和微血管模式，无分界线，并作出非癌症诊断[1]。然而，由于白光成像的内镜特征仍然强烈提示在未被H. pylori，进行活检。在组织学上，观察到类似胃底腺细胞的胃腺癌伴粘膜下浸润（[图1]）。免疫组化染色进一步证实了胃底腺型胃腺癌的病理诊断[2][3]。放大图像图1在胃底大弯（黄色箭头）发现一个2 mm的扁平病变（0-II B），颜色变淡，集合小静脉排列规则：远观;近观B。c窄带成像显示明显的白色病变（黄色箭头）。d活检标本显示胃底腺型胃腺癌伴粘膜下浸润（红色箭头）。
A 64-year-old woman without Helicobacter pylori infection underwent an esophagogastroduodenoscopy during a health examination. A 2-mm flat lesion (0-IIb) with faded color and harboring a regular arrangement of collecting venules was detected at the greater curvature of the gastric fundus. Narrow-band imaging (NBI) showed a distinct whitish lesion. Magnifying endoscopy with NBI revealed a regular microsurface and microvascular pattern without a demarcation line, and a noncancer diagnosis was made [1]. However, as the endoscopic features on white-light imaging still strongly suggested neoplastic lesion in the background of mucosa not infected by H. pylori, a biopsy was taken. Histologically, a gastric adenocarcinoma resembling fundic gland cells with submucosal invasion was seen ([Fig. 1]). A pathological diagnosis of gastric adenocarcinoma of the fundic-gland type [2][3] was further confirmed by immunohistochemical staining.Zoom Image Fig. 1 A 2-mm flat lesion (0-IIb) with faded color and harboring a regular arrangement of collecting venules was detected at the greater curvature of the gastric fundus (yellow arrow): a distant view; b closer view. c Narrow-band imaging showed a distinct whitish lesion (yellow arrow). d A biopsy specimen showed a gastric adenocarcinoma of the fundic-gland type with submucosal invasion (red arrow).