EFFECT ON CUSHING RESPONSE OF DIFFERENT RATES OF EXPANSION OF A SUPRATENTORIAL MASS
EFFECT ON CUSHING RESPONSE OF DIFFERENT RATES OF EXPANSION OF A SUPRATENTORIAL MASS
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DOI：
10.3171/jns.1978.49.1.0061
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发表时间：
1978-01-01
影响因子：
4.1
通讯作者：
GIRVIN, JP
中科院分区：
文献类型：
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作者：
ZIDAN, AH;GIRVIN, JP
研究了猫幕上球囊持续扩张对库欣反应（CR） 3项指标（呼吸、血压和心率）的影响。扩张率在0.006 ~ 0.6 ml/min范围内变化，同时监测全身动脉压、心率、呼吸频率和血气。对于不同的速率，测量了CR发展所需的时间和发展所需的气球体积。诱导CR的最终容积（临界容积）在整个输注速率（球囊扩张）范围内或多或少是恒定的，这一事实支持门罗-凯利学说。这种临界容量（CCV）的恒定性导致了输注速率与CR产生的潜伏期之间具有高度统计学意义的关系。它由功率曲线描述。因此，在这些实验条件下，脑功能障碍的发展与扩张速度无关，只取决于这个临界体积。预测在患者病变扩张率的极端情况下，临界体积概念的例外情况。
The effects on the 3 components (respiration, blood pressure and heart rate) of the Cushing response (CR) were studied in cats by the continuous expansion of a supratentorial balloon. The expansion rate varied over the range of 0.006-0.6 ml/min, during which systemic arterial pressure, heart rate, respiratory rate and blood gases were monitored. For the different rates, both the time that the CR took to develop and the balloon volume required for that development were measured. The final volume (critical volume) for eliciting the CR was more or less constant over the full range of infusion rates (balloon expansion), a fact that supports the Monro-Kellie doctrine. This constancy of critical volume (CCV) gives rise to a highly statistically significant relationship between the infusion rate and the latency to the production of the CR. It is described by a power curve. Thus the development of cerebral dysfunction under these experimental conditions is independent of the expansion rate and only dependent upon this critical volume. Exceptions to this concept of a critical volume, at the extreme of expansion rates of lesions in patients, are predicted.