Estimation of blood-group gene frequencies
Estimation of blood-group gene frequencies
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DOI：
10.1111/j.1469-1809.1938.tb02188.x
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发表时间：
1938-08-01
期刊：
影响因子：
--
通讯作者：
Stevens, WL
中科院分区：
文献类型：
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作者：
Stevens, WL
本文举例说明了人类群体中M-N、O-A-B和O-A1-A2-B基因比例的估计方法和估计的标准误差。O-A1-A2-B系统没有显式解，但用于改进低效估计的最大似然法被简化为相当简洁的常规计算。同样的方法也应该用于O-A-B系统，因为伯恩斯坦方法虽然有效，但不会给出标准误差。给出了检验数据与假设一致性的方法，包括对分类为杂合子和两个纯合子的材料进行新的精确检验(如在M-N系统中)。本文结合O-A1-A2-B基因比例的异质性，首次讨论了参数估计的异质性(不同群体之间)的检验。
The paper explains, with examples, methods for estimating proportions of M-N, O-A-B, and O-A1-A2-B genes in human populations, and of finding standard errors of the estimates. No explicit solution is available for the O-A1-A2-B system, but the method of maximum likelihood, used to improve inefficient estimates, is reduced to a fairly concise routine calculation. The same method should be employed for the O-A-B system, since the Bernstein method, although efficient, does not give standard errors. Methods are given for testing agreement of data with hypotheses, including a new exact test for material classified into heterozygotes and two homo-zygotes (as in the M-N system). The testing of heterogeneity (between different populations) of parametric estimates is here discussed for the first time, in connection with the heterogeneity of O-A1-A2-B gene proportions.