Strain differences in the induction of intestinal metaplasia by X-irradiation in rats
Strain differences in the induction of intestinal metaplasia by X-irradiation in rats
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DOI：
10.1007/bf02934483
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发表时间：
1997-06-01
影响因子：
6.3
通讯作者：
Ito, A
中科院分区：
文献类型：
--
作者：
Watanabe, H;Fujimoto, N;Ito, A
检查了大鼠对 X 射线照射诱导肠化生的易感性的菌株差异。对 5 种近交系大鼠（F344/NSlc、Copenhagen、Buffalo/NacJcl 和 ACI/NHos）和 3 种随机繁殖大鼠（HOS：Donryu、Slc：Wistar、Slc：SD）的 5 周龄雄性大鼠的胃部区域进行总剂量为 20 Gy 的 X 射线照射，每隔 3 天分两次等量照射。在最后一次照射后 6 个月处死大鼠后进行检查，发现碱性磷酸酶 (ALP) 阳性的肠化隐窝数量在 Donryu 大鼠中最高，在 Copenhagen 大鼠中最低。形态学上，Donryu、Wistar、SD和Buffalo大鼠腺胃中肠化生隐窝的数量高于ACI、F344和哥本哈根大鼠。肠化生在幽门中比在胃底腺中更常见。这些结果表明，X射线照射对大鼠肠化生的诱导很大程度上受到大鼠品系的影响。
Strain differences in the susceptibility of rats to induction of intestinal metaplasia by X-irradiation were examined. The gastric regions of 5-week-old males of five inbred strains of rats (F344/NSlc, Copenhagen, Buffalo/NacJcl, and ACI/NHos) and three strains of randomly bred rats (HOS:Donryu, Slc:Wistar, Slc:SD) were irradiated with a total dose of 20 Gy X-ray given in two equal fractions at 3-day intervals. When examined after the rats were killed, 6 months after the last irradiation, the number of intestinal metaplastic crypts positive for alkaline phosphatase (ALP) was highest in the Donryu and lowest in the Copenhagen rats. Morphologically, the number of crypts with intestinal metaplasia in the glandular stomachs of Donryu, Wistar, SD, and Buffalo rats was higher than the number in ACI, F344, and Copenhagen rats. Intestinal metaplasia was more frequently observed in the pyloric than in the fundic glands. These results demonstrate that the induction of intestinal metaplasia by X-irradiation in rats is greatly influenced by the rat strain.