Ruthenium-Catalyzed Amino- and Alkoxycarbonylations with Carbamoyl Chlorides and Alkyl Chloroformates via Aromatic C-H Bond Cleavage
Ruthenium-Catalyzed Amino- and Alkoxycarbonylations with Carbamoyl Chlorides and Alkyl Chloroformates via Aromatic C-H Bond Cleavage
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DOI：
10.1021/ja8097492
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发表时间：
2009-03-04
影响因子：
15
通讯作者：
Kakiuchi, Fumitoshi
中科院分区：
文献类型：
--
作者：
Kochi, Takuya;Urano, Seiya;Kakiuchi, Fumitoshi
描述了钌催化的通过使用氯羰基化合物的C-H键断裂的芳环的区域选择性直接氨基和烷氧基羰基化。利用羰基化剂的广泛可用性实现了酰胺和酯基团的广泛通用性。不适用于通常的Friedel-Crafts方法的氯甲酸烷基酯也可用于直接催化烷氧基羰基化。
Ruthenium-catalyzed regioselective direct amino- and alkoxycarbonylations of aromatic rings via C-H bond cleavage using chlorocarbonyl compounds are described. A broad generality of amide and ester groups was achieved taking advantage of the wide availability of carbonylating agents. Alkyl chloroformates, inapplicable to usual Friedel-Crafts methods, can also be used for direct catalytic alkoxycarbonylation.