Multimodal Optothermal Manipulations along Various Surfaces
Multimodal Optothermal Manipulations along Various Surfaces
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DOI：
10.1021/acsnano.3c00583
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发表时间：
2023-04-05
期刊：
影响因子：
17.1
通讯作者：
Zheng，Yuebing
中科院分区：
文献类型：
--
作者：
Ding，Hongru;Kollipara，Pavana Siddhartha;Zheng，Yuebing
光镊通过提供对小物体的无接触操作，为生命科学、化学和物理学的基础研究和应用提供了巨大的机会。然而，它需要复杂的实时成像和反馈系统的传统光镊，以实现控制运动的微米/纳米粒子沿着纹理表面，这是需要这样的应用，如高分辨率的近场表征的细胞膜与纳米粒子作为探针。此外，大多数光镊系统仅限于单一操作模式，限制了其更广泛的应用。在这里，我们开发了一个光热平台，使多模态操作的微米/纳米粒子沿着各种表面。具体来说，我们通过光学力和热力之间的协同作用实现了对微米/纳米颗粒的操纵，这是由于颗粒吸收光而产生的温度梯度引起的。通过对激光束的简单控制，我们实现了五种可切换的工作模式[即，镊子、旋转、滚动（朝向）、滚动（远离）和射击]，用于合成颗粒和生物细胞沿着各种基底的通用操作。更有趣的是，我们实现了在活蠕虫及其胚胎的粗糙表面上操纵微米/纳米颗粒，以局部控制生物功能。通过使微/纳米物体的三维控制沿着各种表面，包括拓扑不均匀的生物组织，我们的多模态光热平台将成为生命科学，纳米技术和胶体科学的强大工具。
Optical tweezers have provided tremendous opportunities for fundamental studies and applications in the life sciences, chemistry, and physics by offering contact-free manipulation of small objects. However, it requires sophisticated real-time imaging and feedback systems for conventional optical tweezers to achieve controlled motion of micro/nanoparticles along textured surfaces, which are required for such applications as high-resolution near-field characterizations of cell membranes with nanoparticles as probes. In addition, most optical tweezers systems are limited to single manipulation modes, restricting their broader applications. Herein, we develop an optothermal platform that enables the multimodal manipulation of micro/nanoparticles along various surfaces. Specifically, we achieve the manipulation of micro/nanoparticles through the synergy between the optical and thermal forces, which arise due to the temperature gradient self-generated by the particles absorbing the light. With a simple control of the laser beam, we achieve five switchable working modes [i.e., tweezing, rotating, rolling (toward), rolling (away), and shooting] for the versatile manipulation of both synthesized particles and biological cells along various substrates. More interestingly, we realize the manipulation of micro/nanoparticles on rough surfaces of live worms and their embryos for localized control of biological functions. By enabling the three-dimensional control of micro/nano-objects along various surfaces, including topologically uneven biological tissues, our multimodal optothermal platform will become a powerful tool in life sciences, nanotechnology, and colloidal sciences.