Improving lesion-symptom mapping
Improving lesion-symptom mapping
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DOI：
10.1162/jocn.2007.19.7.1081
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发表时间：
2007-07-01
影响因子：
3.2
通讯作者：
Bonilha, Leonardo
中科院分区：
文献类型：
--
作者：
Rorden, Chris;Karnath, Hans-Otto;Bonilha, Leonardo
测量大脑活动（例如，头皮电位的变化）已经成为推断大脑功能最流行的方法。然而，检查大脑中断（例如，检查脑损伤后的行为）可以补充激活研究，激活技术识别与任务相关的区域，而中断技术能够发现哪些区域对任务至关重要。基于体素的病变映射可用于确定行为测量与脑损伤位置之间的关系，揭示脑区域的功能。病变映射也可以将神经外科手术的有效性与脑切除的位置联系起来，确定最佳的手术目标。传统上，基于体素的病变检测在临床测量值为二项时采用卡方检验，在测量值为连续时采用学生t检验。在这里，我们认为利伯迈斯特方法对二项数据比卡方检验更敏感。我们还建议，Brunner和Munzel描述的检验比非二项数据的t检验更合适，因为临床和神经心理学数据经常违反t检验的假设。我们使用模拟数据和从空间感知障碍的中风患者样本中获得的数据，通过对比统计测试来检验我们的假设。我们还开发了实现这些测试的软件（MRicron），免费提供给科学界。
Measures of brain activation (e.g., changes in scalp electrical potentials) have become the most popular method for inferring brain function. However, examining brain disruption (e.g., examining behavior after brain injury) can complement activation studies, Activation techniques identify regions involved with a task, whereas disruption techniques are able to discover which regions are crucial for a task. Voxel-based lesion mapping can be used to determine relationships between behavioral measures and the location of brain injury, revealing the function of brain regions. Lesion mapping can also correlate the effectiveness of neurosurgery with the location of brain resection, identifying optimal Surgical tatrgets. Traditionally, voxel-based lesion rnapping has employed the chi-square test when the clinical measure is binomial and the Student's t test when measures ire continuous. Here We Suggest that the Liebermeister approach for binomial clata is more sensitive than the chi-square test. We also suggest that a test described by Brunner and Munzel is more appropriate than the t test for nonbinomial clata because clinical and neuropsychological clata often violate the assumptions of the t test. We test our hypotheses cornparing statistical, tests using both simulated data and clata obtained from a sample of stroke patients with disturbed spatial perception. We also developed software to implement these tests (MRicron), made freely available to the scientific community.