FACTORS IN PLASMA CONCERNED IN NATURAL RESISTANCE TO AN AVIAN MALARIA PARASITE (PLASMODIUM LOPHURAE).
FACTORS IN PLASMA CONCERNED IN NATURAL RESISTANCE TO AN AVIAN MALARIA PARASITE (PLASMODIUM LOPHURAE).
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DOI：
10.1084/jem.91.4.365
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发表时间：
1950-03-31
期刊：
影响因子：
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通讯作者：
McGhee RB
中科院分区：
文献类型：
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作者：
Trager W;McGhee RB
将成年鸡的血浆注射到感染了lophurae疟原虫的雏鸡或小鸡胚胎中，可减轻寄生虫病。通过在65℃下将成年鸡血浆加热半小时，然后离心去除凝固物质，使产生这种效应的物质失活或去除；但在56°C的温度下加热半小时对它们没有影响。活性物质主要存在于母鸡血浆的优球蛋白部分。在对鸭子进行的类似实验中，研究人员测试了一系列成年鸭子的血浆对雏鸭感染过程的影响。然后给成年鸭子接种了大剂量的寄生虫。血浆在减少用它治疗的雏鸭的寄生虫病方面的有效性与获得血浆的鸭对感染的抵抗力之间存在正相关。对卵巢活跃的成年母鸭进行了检测，半数以上的母鸭有有效的血浆，但只有一只公鸭对感染表现出相对的抵抗力。
The plasma of adult chickens, when injected into young chicks or chick embryos infected with Plasmodium lophurae, lessened the parasitemia. The substances responsible for this effect were inactivated or removed by the heating of adult chicken plasma for ½ hour at 65°C., followed by centrifugation to remove the coagulated material; but they were not affected by heating for ½ hour at 56°C. The active materials were present in the euglobulin fraction of hen plasma. In similar experiments with ducks, the plasma from each of a series of adult ducks was tested for its effect on the course of infection in young ducklings. The adult ducks were then inoculated with a large dose of parasites. There was a positive correlation between the effectiveness of a plasma in lessening the parasitemia of ducklings treated with it and the resistance on infection exhibited by the duck from which the plasma had been obtained. More than half of the adult female ducks with an active ovary which were tested, but only one of the males, had effective plasmas and also showed relative resistance to the infection.