Cytoarchitectonic identification and probabilistic mapping of two distinct areas within the anterior ventral bank of the human intraparietal sulcus
Cytoarchitectonic identification and probabilistic mapping of two distinct areas within the anterior ventral bank of the human intraparietal sulcus
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DOI：
10.1002/cne.20849
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发表时间：
2006-03-01
影响因子：
2.5
通讯作者：
Amunts, K
中科院分区：
文献类型：
--
作者：
Choi, HJ;Zilles, K;Amunts, K
猕猴皮层的解剖学研究和人类的功能成像研究表明，顶内沟（IPS）内存在不同的皮层区域。然而，这种功能分离与目前可用的人脑结构图无关。这对于经典的Brodmann图尤其如此，Brodmann图仍然被广泛用作功能成像研究中的解剖参考。该细胞结构映射研究的目的是使用先前定义的算法来确定是否可以在10个死后人类大脑的前IPS的皮质内找到一致的区域和边界。两个区域，人顶内区1（hIP 1）和人顶内区2（hIP 2），描绘在连续的组织切片的前，外侧银行的人IPS。hIP 1区位于hIP 2区的后内侧，且hIP 1区始终位于IPS的深部。另一方面，后者有时到达上级顶叶小叶的游离面。将划定登记到标准参考空间，并计算概率图，从而量化两个区域的位置和范围的受试者间差异。在未来，它们可以成为分析结构-功能关系的工具，并为确定灵长类动物IPS的同源性程度奠定基础。我们的结论是，人类IPS有一个更细粒度的包裹比Brodmann的地图。J. Comp.神经元495：53-69，2006年。(c)2006 Wiley-Liss，Inc.
Anatomical studies in the macaque cortex and functional imaging studies in humans have demonstrated the existence of different cortical areas within the intraparietal sulcus (IPS). Such functional segregation, however, does not correlate with presently available architectonic maps of the human brain. This is particularly true for the classical Brodmann map, which is still widely used as an anatomical reference in functional imaging studies. The aim of this cytoarchitectonic mapping study was to use previously defined algorithms to determine whether consistent regions and borders can be found within the cortex of the anterior IPS in a population of 10 post-mortem human brains. Two areas, the human intraparietal area 1 (hIP1) and the human intraparietal area 2 (hIP2), were delineated in serial histological sections of the anterior, lateral bank of the human IPS. The region hIP1 is located posterior and medial to hIP2, and the former is always within the depths of the IPS. The latter, on the other hand, sometimes reaches the free surface of the superior parietal lobule. The delineations were registered to standard reference space, and probabilistic maps were calculated, thereby quantifying the intersubject variability in location and extent of both areas. In the future, they can be a tool for analyzing structure-function relationships and a basis for determining degrees of homology in the IPS among anthropoid primates. We conclude that the human IPS has a more finely grained parcellation than shown in Brodmann's map. J. Comp. Neurol. 495:53-69, 2006. (c) 2006 Wiley-Liss, Inc.