Initial Surgical Versus Conservative Strategies in Patients With Asymptomatic Severe Aortic Stenosis
Initial Surgical Versus Conservative Strategies in Patients With Asymptomatic Severe Aortic Stenosis
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DOI：
10.1016/j.jacc.2015.10.001
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发表时间：
2015-12-29
影响因子：
24
通讯作者：
Kimura, Takeshi
中科院分区：
文献类型：
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作者：
Taniguchi, Tomohiko;Morimoto, Takeshi;Kimura, Takeshi
背景目前的指南通常建议在无症状的严重主动脉瓣狭窄（AS）患者中观察等待直到症状出现才进行主动脉瓣置换（AVR）。结论该研究试图比较诊断为无症状的严重AS后初始AVR与保守策略的长期结果。815例连续重度AS患者（峰值主动脉射流速度>4.0 m/s，或平均主动脉压差>40 mm Hg，或主动脉瓣面积
BACKGROUND Current guidelines generally recommend watchful waiting until symptoms emerge for aortic valve replacement (AVR) in asymptomatic patients with severe aortic stenosis (AS).OBJECTIVES The study sought to compare the long-term outcomes of initial AVR versus conservative strategies following the diagnosis of asymptomatic severe AS.METHODS We used data from a large multicenter registry enrolling 3,815 consecutive patients with severe AS (peak aortic jet velocity >4.0 m/s, or mean aortic pressure gradient >40 mm Hg, or aortic valve area