Smart Shape-Memory Polymeric String for the Contraction of Blood Vessels in Fetal Surgery of Sacrococcygeal Teratoma
Smart Shape-Memory Polymeric String for the Contraction of Blood Vessels in Fetal Surgery of Sacrococcygeal Teratoma
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DOI：
10.1002/adhm.202200050
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发表时间：
2022-04-23
影响因子：
10
通讯作者：
Ebara, Mitsuhiro
中科院分区：
文献类型：
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作者：
Fulati, Ailifeire;Uto, Koichiro;Ebara, Mitsuhiro
形状记忆聚合物（SMPs）因其独特的形状记忆特性，在众多新兴生物医学应用领域中颇具潜力。然而，要同时实现高强度、高韧性、高拉伸性，且保持高形状固定率（R - f）和形状回复率（R - r），仍是一项挑战，这阻碍了它们的实际应用。在此，本文报道了一种新型形状记忆聚合物线（SMP线），通过一种简便方法，仅用四支化聚己内酯（PCL）制备而成，该SMP线具有超拉伸性（高达1570%）、高强度（高达345兆帕）、高韧性（高达237.9兆焦/立方米）以及高回复性（R - f平均高于99.5%，R - r平均高于99.1%）。值得注意的是，这种SMP线的形状记忆收缩力（高达7.97牛）可通过调整线的厚度和拉伸性来调控其能量存储能力，从而实现定制。此外，该SMP线展现出可控的形状记忆响应时间，并且对刚性硅胶管和猪颈动脉均表现出出色的形状记忆诱导收缩效果。这种新型SMP线有望应用于血管收缩，解决了诸如骶尾部畸胎瘤（SCT）胎儿镜手术等微创手术中血流限制方面的难题。
Shape-memory polymers (SMPs) are promising materials in numerous emerging biomedical applications owing to their unique shape-memory characteristics. However, simultaneous realization of high strength, toughness, stretchability while maintaining high shape fixity (R-f) and shape recovery ratio (R-r) remains a challenge that hinders their practical applications. Herein, a novel shape-memory polymeric string (SMP string) that is ultra-stretchable (up to 1570%), strong (up to 345 MPa), tough (up to 237.9 MJ m(-3)), and highly recoverable (R-f averagely above 99.5%, R-r averagely above 99.1%) through a facile approach fabricated solely by tetra-branched poly(epsilon-caprolactone) (PCL) is reported. Notably, the shape-memory contraction force (up to 7.97 N) of this SMP string is customizable with the manipulation of their energy storage capacity by adjusting the string thickness and stretchability. In addition, this SMP string displays a controllable shape-memory response time and demonstrates excellent shape-memory-induced contraction effect against both rigid silicone tubes and porcine carotids. This novel SMP string is envisioned to be applied in the contraction of blood vessels and resolves the difficulties in the restriction of blood flow in minimally invasive surgeries such as fetoscopic surgery of sacrococcygeal teratoma (SCT).