Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population.
Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population.
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DOI：
10.1590/s1415-47572012005000029
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发表时间：
2012-04
影响因子：
2.1
通讯作者：
Samaei NM
中科院分区：
文献类型：
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作者：
Alami FM;Ahmadi M;Bazrafshan H;Tabarraei A;Khosravi A;Tabatabaiefar MA;Samaei NM
在全球不同人群中，TCF 7 L2（转录因子7样2）基因的常见变异与2型糖尿病（T2 DM）的风险相关。目的是调查伊朗人群TCF 7 L2基因rs 12255372（G/T）多态性与T2 DM之间的关联。研究了236例无关的T2 DM患者和255例无糖尿病的血糖正常对照。采用PCR-RFLP方法对rs 12255372（G/T）多态性进行分型，统计学分析采用SPSS18.0forWindows软件包。发现TCF 7 L2 rs 12255372的次要T等位基因显著增加T2 DM的风险，等位基因比值比（OR）为1.458（95% CI 1.108-1.918，p = 0.007）。TT基因型在T2 DM患者和血糖正常对照组之间存在显著差异（OR 2.038，95%CI 1.147-3.623; p = 0.014）。在假设显性和隐性模型时，获得的OR分别为1.52 [95% CI（1.05-2.21）p = 0.026）]和1.74 [95% CI（1.01-3.00）p = 0.043]，从而表明共显性模型最适合易感基因效应。这项研究进一步证实了TCF 7 L2基因增强了T2 DM的易感性。
In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. The PCR-RFLP method was used for genotyping rs12255372 (G/T) polymorphism, and the SPSS version 18.0 for Windows for statistical analysis. The minor T allele of TCF7L2 rs12255372 was found to significantly increase the risk of T2DM, with an allelic odds ratio (OR) of 1.458 (95% CI 1.108–1.918, p = 0.007). A significant difference in TT genotype was observed between T2DM patients and normoglycemic controls (OR 2.038, 95% CI 1.147–3.623; p = 0.014). On assuming dominant and recessive models, ORs of 1.52 [95% CI (1.05–2.21) p = 0.026)] and 1.74 [95% CI (1.01–3.00) p = 0.043] were obtained, respectively, thereby implying that the co-dominant model would best fit the susceptible gene effect. This study further confirms the TCF7L2 gene as enhancing susceptibility to the development of T2DM.