Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran
Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran
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DOI：
10.1039/c0cc01682a
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Andreasson, Joakim
中科院分区：
文献类型：
--
作者：
Hammarson, Martin;Andersson, Johanna;Andreasson, Joakim
使用UV光和质子将螺吡喃光开关从不显示与DNA相互作用的形式激活为通过嵌入与DNA结合的形式。该方案被解释为一个生物相关的逻辑与门与潜在的应用作为一个双重控制的抗癌药物。
A spiropyran photoswitch is activated using UV light and protons from a form that shows no interaction with DNA to a form that binds to DNA by intercalation. This scheme is interpreted as a biologically relevant logic AND gate with potential applications as a dually controlled anticancer drug.