Dysfunction in the neural circuitry of emotional self-regulation in major depressive disorder
Dysfunction in the neural circuitry of emotional self-regulation in major depressive disorder
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DOI：
10.1097/01.wnr.0000220132.32091.9f
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发表时间：
2006-05-29
期刊：
影响因子：
1.7
通讯作者：
Levesque, Johanne
中科院分区：
文献类型：
--
作者：
Beauregard, Mario;Paquette, Vincent;Levesque, Johanne
自我调节负面情绪的能力似乎在严重抑郁障碍的发生中起着关键作用。这种无能为力可能与情绪自我调节的神经回路功能障碍有关。这项功能磁共振成像研究就是为了验证这一假说。当抑郁的个体和对照组试图自愿降低悲伤情绪时，他们被扫描。抑郁的个体在下调悲伤的过程中所经历的困难程度更高。此外，抑郁症患者的右侧背侧扣带前皮质、右侧前颞极、右侧杏仁核和右侧脑岛的激活程度更高。这些结果表明，重度抑郁障碍患者的情绪调节障碍与情绪自我调节神经回路的紊乱有关。
An inability to self-regulate negative emotions appears to play a pivotal role in the genesis of major depressive disorder. This inability may be related to a dysfunction of the neural circuitry underlying emotional self-regulation. This functional magnetic resonance imaging study was conducted to test this hypothesis. Depressed individuals and controls were scanned while they attempted to voluntarily down-regulate sad feelings. The degree of difficulty experienced during down-regulation of sadness was higher in depressed individuals. Furthermore, there was greater activation in the right dorsal anterior cingulate cortex, right anterior temporal pole, right amygdala, and right insula in depressed individuals. These results suggest that emotional dysregulation in major depressive disorder is related to a disturbance in the neural circuitry of emotional self-regulation.