Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. II. Identified neurons produce heterosynaptic facilitation contributing to behavioral sensitization.
Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. II. Identified neurons produce heterosynaptic facilitation contributing to behavioral sensitization.
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中间神经元参与海兔退鳃反射的介导和调节。
DOI：
10.1152/jn.1981.45.2.315
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发表时间：
1981
影响因子：
2.5
通讯作者：
Kandel,ER
中科院分区：
文献类型：
--
作者：
Hawkins,RD;Castellucci,VF;Kandel,ER
3. 刺激同一神经节中至少两种不同的L29细胞可产生复杂PSP的促进作用。此外，刺激L22和L28神经元也分别在24%和30%的情况下产生促进作用。由于所有这些神经元在刺激胸腹结缔组织时通常会放电，它们的联合作用可能足以解释结缔组织刺激产生的促进作用，这种促进作用通常比刺激单个神经元产生的促进作用更大。4. L29神经元的刺激产生单一的感觉-运动神经元PSP的促进作用，这可能足以解释L29对复杂PSP的大部分促进作用。另一方面，L22的刺激通过另一种机制促进复杂的PSP：神经元间-运动神经元突触的PTP。5. L16的刺激产生对PSP复合物的抑制作用，这种抑制作用比刺激持续时间长约1分钟。这种效应的机制尚未被研究。
3. Stimulation of at least two different L29 cells in the same ganglion can produce facilitation of the complex PSP. In addition, stimulation of L22 and L28 neurons also produces facilitation in 24 and 30% of the cases, respectively. Since all of these neurons normally fire during stimulation of a pleuroabdominal connective their combined action may be sufficient to account for the facilitation produced by connective stimulation, which is generally greater than that produced by stimulation of a single neuron. 4. Stimulation of an L29 neuron produces facilitation of unitary sensory-to-motor neuron PSPs, which may be sufficient to account for most of the facilitation of the complex PSP by L29. Stimulation of L22, on the other hand, produces facilitation of the complex PSP by an additional mechanism: PTP at the interneuron-to-motor neuron synapse. 5. Stimulation of L16 produces inhibition of the complex PSP, which outlasts the stimulation by about 1 min. The mechanism of this effect has not yet been investigated.