Effects of N-terminal fragments of β-endorphin on feeding in chicks
Effects of N-terminal fragments of β-endorphin on feeding in chicks
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DOI：
10.1016/j.neulet.2008.07.018
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发表时间：
2008-09-12
影响因子：
2.5
通讯作者：
Bungo, Takashi
中科院分区：
文献类型：
--
作者：
Yanagita, Kouichi;Shiraishi, Jun-Ichi;Bungo, Takashi
已知β-内啡肽的N-末端片段具有生物活性，例如β-内啡肽（1-31）对哺乳动物的激素分泌或体温调节的拮抗作用。研究了N-末端片段对雄性肉仔鸡摄食行为的影响。脑室内注射β-内啡肽（1-27）（0.4 nmol）刺激摄食行为相比，生理盐水对照在60分钟的实验期间。β-内啡肽（1-17）（2.0 nmol）也增加了注射后30分钟的摄食量。共注射β-内啡肽（1-27）或（1-17）可有效减少全长β-内啡肽诱导的雏鸡摄食。这些数据表明，β-内啡肽的N-末端片段作为一个部分激动剂，并可能调节中枢阿片系统的活动在小鸡。(c)2008爱思唯尔爱尔兰有限公司保留所有权利。
It is known that N-terminal fragments of beta-endorphin have biological activities, such as an antagonism effect of beta-endorphin (1-31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of beta-endorphin (1-27) (0.4 nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. beta-Endorphin (1-17) (2.0 nmol) also increased food intake at 30 min postinjection. Co-injection of either beta-endorphin (1-27) or (1-17) was effective in reducing full-length beta-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of beta-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks. (c) 2008 Elsevier Ireland Ltd. All rights reserved.