Impact of smoking on choroidal microvasculature dropout in glaucoma: a cross-sectional study.
Impact of smoking on choroidal microvasculature dropout in glaucoma: a cross-sectional study.
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DOI：
10.1136/bmjophth-2023-001421
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发表时间：
2023-10
影响因子：
2.4
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中科院分区：
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目的探讨吸烟对青光眼患者脉络膜微血管丢失(MVD)的影响。横断面研究。第三级青光眼中心。对163例223眼原发性开角型青光眼患者进行了光学相干断层扫描血管成像，并填写了青光眼诊断创新研究中关于吸烟的调查问卷。采用线性混合效应模型分析各参数对MVD面积和角周长的影响。根据视野平均偏差(MD)对青光眼严重程度进行分类，进行敏感性分析。有吸烟史者37眼(51.4%)，非吸烟者67眼(44.4%)(P=0.389)。与非吸烟者相比，吸烟者的微血管面积和角围均较大(p=0.068 和p=0.046)。在多变量模型中，吸烟强度与MVD面积显著相关(每10包年每0.01mm2吸烟0.30(95%可信区间0.01~0.60)；p=0.044)。在中重度青光眼(MD<；−6)中，吸烟强度与更大的微血管面积相关(每10包年每0.01mm2，吸烟0.47(95%CI 0.11~0.83)；p=0.011)，而在早期青光眼(MD≥−6)中未发现明显的相关性(−0.08(95%CI−0.26~0.11)，p=0.401)。在青光眼患者中，吸烟强度与脉络膜MVD面积的增大有关，尤其是在病情较严重的患者中。NCT00221897。
To investigate the effect of smoking on choroidal microvasculature dropout (MvD) in glaucoma. Cross-sectional study. Tertiary glaucoma centre. 223 eyes of 163 patients with primary open-angle glaucoma who had undergone imaging with optical coherence tomography angiography and completed a questionnaire on smoking from the Diagnostic Innovations in Glaucoma Study. Linear mixed-effects models were used to determine the effect of each parameter on MvD area and angular circumference. The sensitivity analysis was performed by categorising the glaucoma severity determined by visual field mean deviation (MD). MvD was found in 37 (51.4%) eyes with smoking history and in 67 (44.4%) eyes with non-smokers (p=0.389). Larger MvD area and wider angular circumference were found in smokers compared with non-smokers (p=0.068 and p=0.046, respectively). In a multivariable model, smoking intensity was significantly associated with MvD area (0.30(95% CI 0.01 to 0.60) each 0.01 mm2 per 10 pack-years; p=0.044). In eyes with moderate-severe glaucoma (MD <−6), smoking intensity was associated with larger MvD area (0.47 (95% CI 0.11 to 0.83) each 0.01 mm2 per 10 pack-years; p=0.011), whereas no significant association was found in early glaucoma (MD ≥−6) (−0.08 (95% CI −0.26 to 0.11), p=0.401). Smoking intensity was associated with larger choroidal MvD area in eyes with glaucoma, especially in patients with more severe disease. NCT00221897.